Seroatlas · Human Serome Atlas

RUSF1

RUS family member 1

Also known as: C16orf58, FLJ13868, RUSF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GQ5
Gene: RUSF1
Ensembl: ENSG00000140688
Chromosome: 16
Canonical length: 468 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q96GQ5|RUSF1
     1  MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV
    61  GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG
   121  VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI
   181  MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL
   241  AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
   301  QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ
   361  SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV
   421  KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUSF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 61 nTPM
liver: 55 nTPM
pancreas: 54 nTPM
ovary: 48 nTPM
pituitary gland: 46 nTPM
cervix: 44 nTPM

Single-cell type

cardiomyocytes: 49 nCPM
breast lactating cells: 43 nCPM
plasma cells: 36 nCPM
tuft cells: 35 nCPM
syncytiotrophoblasts: 33 nCPM
pancreatic acinar cells: 32 nCPM

Immune cell

myeloid DC: 9.7 nTPM
NK-cell: 9.5 nTPM
T-reg: 9.5 nTPM
plasmacytoid DC: 8.9 nTPM
intermediate monocyte: 8.4 nTPM
memory CD4 T-cell: 8.2 nTPM

Brain region

hypothalamus: 41 nTPM
cerebral cortex: 41 nTPM
basal ganglia: 40 nTPM
pons: 39 nTPM
medulla oblongata: 36 nTPM
hippocampal formation: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Root UVB sensitive family
Protein root UVB sensitive/RUS domain
Root UVB sensitive protein, C-terminal
Vitamin B6 photo-protection and homoeostasis domain
Root UVB sensitive protein, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RUSF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUSF1 as an antibody target. Whether an autoantibody or antibody against RUSF1 could matter depends on whether native RUSF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUSF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RUSF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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