ZC3H8
Zinc finger CCCH domain-containing protein 8
Also known as: Fliz1, ZC3H8_HUMAN, ZC3HDC8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N5P1
- Gene
- ZC3H8
- Ensembl
- ENSG00000144161
- Chromosome
- 2
- Canonical length
- 291 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of DNA-templated transcription; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
291 residues, UniProt reviewed canonical sequence.
>Q8N5P1|ZC3H8
1 MDFENLFSKP PNPALGKTAT DSDERIDDEI DTEVEETQEE KIKLECEQIP KKFRHSAISP
61 KSSLHRKSRS KDYDVYSDND ICSQESEDNF AKELQQYIQA REMANAAQPE ESTKKEGVKD
121 TPQAAKQKNK NLKAGHKNGK QKKMKRKWPG PGNKGSNALL RNSGSQEEDG KPKEKQQHLS
181 QAFINQHTVE RKGKQICKYF LERKCIKGDQ CKFDHDAEIE KKKEMCKFYV QGYCTRGENC
241 LYLHNEYPCK FYHTGTKCYQ GEYCKFSHAP LTPETQELLA KVLDTEKKSC KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZC3H8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 7.2 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 7.2 nTPM
- skeletal muscle: 6.5 nTPM
- pituitary gland: 5.3 nTPM
- retina: 5.1 nTPM
- cerebral cortex: 5 nTPM
- skin: 4.9 nTPM
Single-cell type
- lactotrophs: 115 nCPM
- somatotrophs: 105 nCPM
- thyrotrophs: 101 nCPM
- myonuclei: 95 nCPM
- late primary spermatocytes: 74 nCPM
- brain inhibitory neurons: 73 nCPM
Immune cell
- basophil: 2.3 nTPM
- naive CD4 T-cell: 1.3 nTPM
- NK-cell: 1.3 nTPM
- MAIT T-cell: 1.1 nTPM
- naive B-cell: 1.1 nTPM
- plasmacytoid DC: 1 nTPM
Brain region
- cerebellum: 12 nTPM
- cerebral cortex: 10 nTPM
- hippocampal formation: 8.9 nTPM
- white matter: 8.5 nTPM
- amygdala: 8.4 nTPM
- basal ganglia: 8.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.56
- gnomAD pLI
- 0.26
- gnomAD missense Z
- 1.39
- DepMap mean gene effect
- -0.83
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- negative regulation of DNA-templated transcription
- negative regulation of T cell differentiation in thymus
- positive regulation of thymocyte apoptotic process
- positive regulation of transcription by RNA polymerase III
- response to antibiotic
- snRNA transcription by RNA polymerase II
- snRNA transcription by RNA polymerase III
- T cell homeostasis
Molecular functions
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZC3H8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZC3H8 as an antibody target. Whether an autoantibody or antibody against ZC3H8 could matter depends on whether native ZC3H8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZC3H8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZC3H8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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