Seroatlas · Human Serome Atlas

GTF2E1

General transcription factor IIE subunit 1

Also known as: FE, T2EA_HUMAN, TFIIE-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29083
Gene
GTF2E1
Ensembl
ENSG00000153767
Chromosome
3
Canonical length
439 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>P29083|GTF2E1
     1  MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR
    61  SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD
   121  STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF
   181  NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA
   241  TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI
   301  DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE
   361  SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP
   421  EEKEAYIAMG QRMFEDLFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF2E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.3 nTPM
  • tongue: 8.7 nTPM
  • lymph node: 8.5 nTPM
  • tonsil: 8.5 nTPM
  • thymus: 7.8 nTPM
  • spleen: 7.3 nTPM

Single-cell type

  • megakaryocytes: 31 nCPM
  • differentiating spermatogonia: 28 nCPM
  • choroid plexus epithelial cells: 24 nCPM
  • adrenal cortex cells: 22 nCPM
  • breast lactating cells: 22 nCPM
  • undifferentiated spermatogonia: 21 nCPM

Immune cell

  • basophil: 18 nTPM
  • eosinophil: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • NK-cell: 11 nTPM
  • non-classical monocyte: 11 nTPM
  • T-reg: 10 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • white matter: 9.7 nTPM
  • medulla oblongata: 9.4 nTPM
  • cerebral cortex: 9.3 nTPM
  • midbrain: 8.9 nTPM
  • pons: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GTF2E1.

Disease | ImmuneIEDB

Conditions an epitope on GTF2E1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.89
gnomAD missense Z
1.09
DepMap mean gene effect
-1.23
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF2E1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF2E1 as an antibody target. Whether an autoantibody or antibody against GTF2E1 could matter depends on whether native GTF2E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF2E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF2E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTF2E1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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