Seroatlas · Human Serome Atlas

TCF25

Ribosome quality control complex subunit TCF25

Also known as: KIAA1049, Nulp1, TCF25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQ70
Gene
TCF25
Ensembl
ENSG00000141002
Chromosome
16
Canonical length
676 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>Q9BQ70|TCF25
     1  MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG AGKEGVRVNN
    61  RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG NTESKTDGDD TETVPSEQSH
   121  ASGKLRKKKK KQKNKKSSTG EASENGLEDI DRILERIEDS TGLNRPGPAP LSSRKHVLYV
   181  EHRHLNPDTE LKRYFGARAI LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE
   241  SKKGLSFFAF EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
   301  DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ MSFLEKRGCP
   361  RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI RLFQEWEAHR NLSQLPNFAF
   421  SVPLAYFLLS QQTDLPECEQ SSARQKASLL IQQALTMFPG VLLPLLESCS VRPDASVSSH
   481  RFFGPNAEIS QPPALSQLVN LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC
   541  ENRRKVLYQR APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER
   601  LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR DMMANFHLND
   661  LEAPHEDDAE GEGEWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCF25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 93 nTPM
  • cerebral cortex: 93 nTPM
  • adrenal gland: 86 nTPM
  • blood vessel: 86 nTPM
  • pancreas: 83 nTPM
  • basal ganglia: 82 nTPM

Single-cell type

  • syncytiotrophoblasts: 491 nCPM
  • late spermatids: 451 nCPM
  • retinal horizontal cells: 365 nCPM
  • retinal ganglion cells: 348 nCPM
  • late primary spermatocytes: 324 nCPM
  • retinal amacrine cells: 321 nCPM

Immune cell

  • neutrophil: 223 nTPM
  • plasmacytoid DC: 146 nTPM
  • classical monocyte: 132 nTPM
  • basophil: 125 nTPM
  • eosinophil: 108 nTPM
  • intermediate monocyte: 108 nTPM

Brain region

  • cerebral cortex: 143 nTPM
  • pons: 137 nTPM
  • hypothalamus: 134 nTPM
  • amygdala: 124 nTPM
  • basal ganglia: 123 nTPM
  • thalamus: 122 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.42
gnomAD missense Z
-0.04
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCF25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCF25 as an antibody target. Whether an autoantibody or antibody against TCF25 could matter depends on whether native TCF25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCF25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCF25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCF25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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