TXN2

Protein identityUniProt · HPA

UniProt accession

Q99757

Gene

TXN2

Ensembl

ENSG00000100348

Chromosome

22

Canonical length

166 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q99757|TXN2
     1  MAQRLLLRRF LASVISRKPS QGQWPPLTSR ALQTPQCSPG GLTVTPNPAR TIYTTRISLT
    61  TFNIQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL EKMVAKQHGK VVMAKVDIDD
   121  HTDLAIEYEV SAVPTVLAMK NGDVVDKFVG IKDEDQLEAF LKKLIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

177 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TXN2.

Disease | AllUniProt

Conditions TXN2 is implicated in, by any mechanism.

• Combined oxidative phosphorylation deficiency 29 (COXPD29) MIM:616811

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 78 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Combined oxidative phosphorylation deficiency 29

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.73

gnomAD pLI

0

gnomAD missense Z

0.61

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• sulfur amino acid catabolic process

Molecular functions

• oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
• protein-disulfide reductase activity

Cellular components

• mitochondrial matrix
• mitochondrion
• nucleolus

Protein domainsUniProt · Pfam · InterPro

• Thioredoxin
• Thioredoxin domain
• Thioredoxin, conserved site
• Thioredoxin-like superfamily
• Thioredoxin

KeywordsUniProt

• Acetylation
• Disulfide bond
• Electron transport
• Mitochondrion
• Neurodegeneration
• Primary mitochondrial disease
• Redox-active center
• Transit peptide
• Transport

InteractionsUniProt · HPA

Protein binding partners of TXN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GPRASP2