Seroatlas · Human Serome Atlas

GMEB2

Glucocorticoid modulatory element-binding protein 2

Also known as: GMEB2_HUMAN, KIAA1269, P79PIF, PIF79

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKD1
Gene: GMEB2
Ensembl: ENSG00000101216
Chromosome: 20
Canonical length: 530 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9UKD1|GMEB2
     1  MATPDVSVHM EEVVVVTTPD TAVDGSGVEG VKTVLVTTNL APHGGDLTED NMETENAAAA
    61  AAAAFTASSQ LKEAVLVKMA EEGENLEAEI VYPITCGDSR ANLIWRKFVC PGINVKCVQY
   121  DEHVISPKEF VHLAGKSTLK DWKRAIRMNG IMLRKIMDSG ELDFYQHDKV CSNTCRSTKI
   181  DLSGARVSLS SPTSAEYIPL TPAAADVNGS PATITIETCE DPGDWTAAIG DDTFTFWRGL
   241  KDAGLLDEVI QEFHQELVET MRGLQQRVQD PPLQLRDAVL LNNIVQNFGM LDLVKKVLAS
   301  HKCQMDRSRE QYARDLAALE QQCDEHRRRA KELKHKSQHL SNVLMTLTPV SLPPPVKRPR
   361  LARATSGPAA MASQVLTQSA QLALGPGVPV PQLTSVPLGK VVSTLPSTVL GKGSLQAPPA
   421  SSPASPLLGG YTVLASSGST YPSTVEIHPD ASSLTVLSTA AVQDGSTVFK VVSPLQLLTL
   481  PGLGPTLQNV AQASPGSSTI VTVPAGAAPG PEEHTATIEV AAMAEDHERK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMEB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
thyroid gland: 15 nTPM
testis: 13 nTPM
cerebellum: 11 nTPM
spleen: 10 nTPM
pancreas: 9.5 nTPM

Single-cell type

neutrophils: 67 nCPM
late primary spermatocytes: 51 nCPM
neutrophil progenitors: 48 nCPM
syncytiotrophoblasts: 39 nCPM
breast myoepithelial cells: 35 nCPM
erythrocyte progenitors: 32 nCPM

Immune cell

non-classical monocyte: 2.5 nTPM
gdT-cell: 1.7 nTPM
neutrophil: 1.7 nTPM
naive CD4 T-cell: 1.6 nTPM
MAIT T-cell: 1.5 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

cerebellum: 10 nTPM
medulla oblongata: 10 nTPM
thalamus: 10 nTPM
amygdala: 10 nTPM
cerebral cortex: 10 nTPM
hippocampal formation: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GMEB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMEB2 as an antibody target. Whether an autoantibody or antibody against GMEB2 could matter depends on whether native GMEB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMEB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMEB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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