Seroatlas · Human Serome Atlas

GFRA4

GDNF family receptor alpha-4

Also known as: GFRA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZZ7
Gene: GFRA4
Ensembl: ENSG00000125861
Chromosome: 20
Canonical length: 299 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9GZZ7|GFRA4
     1  MVRCLGPALL LLLLLGSASS VGGNRCVDAA EACTADARCQ RLRSEYVAQC LGRAAQGGCP
    61  RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT FVPSCAFSGP GPAPPSCLEP
   121  LNFCERSRVC RCARAAAGPW RGWGRGLSPA HRPPAAQASP PGLSGLVHPS AQRPRRLPAG
   181  PGRPLPARLR GPRGVPAGTA VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR
   241  CLDGAIQAFA SGWPPVLLDQ LNPQGDPEHS LLQVSSTGRA LERRSLLSIL PVLALPALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GFRA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 1 nTPM
amygdala: 0.5 nTPM
hippocampal formation: 0.5 nTPM
testis: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM

Single-cell type

late spermatids: 5.1 nCPM
smooth muscle cells: 2.7 nCPM
early spermatids: 1.3 nCPM
late primary spermatocytes: 0.8 nCPM
retinal amacrine cells: 0.7 nCPM
esophageal apical cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 0.6 nTPM
hypothalamus: 0.5 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.4 nTPM
midbrain: 0.4 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glial cell-derived neurotrophic factor receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GFRA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GFRA4 as an antibody target. Whether an autoantibody or antibody against GFRA4 could matter depends on whether native GFRA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GFRA4 is annotated at the cell surface, where native GFRA4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GFRA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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