Glial cell line-derived neurotrophic factor receptor
IPR003438
Definition
Glial cell line-derived neurotrophic factor (GDNF) and its related factors neurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNF family of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved in the promotion of neurone survival, exerting their effects through specific receptors. The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked, cell surface receptors PMID:10356294. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-1 and 2 are activated by GDNF and NTN respectively, although some degree of ligand promiscuity is thought to occur PMID:9192684. Homologues for these receptor subtypes have been cloned from mammalian and avian tissue. The principal ligand for GFRalpha-3 is artemin. This receptor subtype is currently described only in mammals PMID:9576965. GFRalpha-4 is activated by persephin and has so far only been found in chicken PMID:9647690. This entry is general for types 1 to 3. Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways PMID:10356294.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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