Seroatlas · Human Serome Atlas

PSPN

Persephin

Also known as: PSP, PSPN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60542
Gene: PSPN
Ensembl: ENSG00000125650
Chromosome: 19
Canonical length: 156 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>O60542|PSPN
     1  MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR
    61  ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG
   121  GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 3.6 nTPM
cerebral cortex: 2.2 nTPM
kidney: 2 nTPM
liver: 1.7 nTPM
amygdala: 1.6 nTPM
basal ganglia: 1.6 nTPM

Single-cell type

late spermatids: 56 nCPM
parietal cells: 7.1 nCPM
early spermatids: 6.9 nCPM
enterocytes: 5.9 nCPM
respiratory deuterosomal cells: 4.1 nCPM
neuroendocrine cells: 4 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 0.8 nTPM
MAIT T-cell: 0.7 nTPM
non-classical monocyte: 0.7 nTPM
plasmacytoid DC: 0.6 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 7.7 nTPM
hypothalamus: 7.2 nTPM
basal ganglia: 7.1 nTPM
amygdala: 7 nTPM
hippocampal formation: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSPN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GFRA4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSPN as an antibody target. Whether an autoantibody or antibody against PSPN could matter depends on whether native PSPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSPN is annotated as secreted, so native PSPN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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