Seroatlas · Human Serome Atlas

GFRA3

GDNF family receptor alpha-3

Also known as: GFRa-3, GFRA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60609
Gene
GFRA3
Ensembl
ENSG00000146013
Chromosome
5
Canonical length
400 aa
Protein class
Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>O60609|GFRA3
     1  MVRPLNPRPL PPVVLMLLLL LPPSPLPLAA GDPLPTESRL MNSCLQARRK CQADPTCSAA
    61  YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG CMCHRRMKNQ VACLDIYWTV
   121  HRARSLGNYE LDVSPYEDTV TSKPWKMNLS KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK
   181  AYGEACSGPH CQRHVCLRQL LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA
   241  LPPVAPNCLE LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM
   301  TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR FHSQLFSQDW
   361  PHPTFAVMAH QNENPAVRPQ PWVPSLFSCT LPLILLLSLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GFRA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • colon: 13 nTPM
  • vagina: 7.1 nTPM
  • cervix: 6.7 nTPM
  • stomach: 6.3 nTPM
  • heart muscle: 5.6 nTPM
  • seminal vesicle: 5.5 nTPM

Single-cell type

  • schwann cells: 75 nCPM
  • neuroendocrine cells: 63 nCPM
  • oocytes: 51 nCPM
  • late spermatids: 35 nCPM
  • differentiating spermatogonia: 8.2 nCPM
  • early spermatids: 8.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 5.2 nTPM
  • cerebral cortex: 0.6 nTPM
  • pons: 0.5 nTPM
  • hypothalamus: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • spinal cord: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.03
gnomAD missense Z
2.05
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GFRA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GFRA3 as an antibody target. Whether an autoantibody or antibody against GFRA3 could matter depends on whether native GFRA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GFRA3 is annotated at the cell surface, where native GFRA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GFRA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GFRA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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