ARTN

Protein identityUniProt · HPA

UniProt accession

Q5T4W7

Gene

ARTN

Ensembl

ENSG00000117407

Chromosome

1

Canonical length

220 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q5T4W7|ARTN
     1  MELGLGGLST LSHCPWPRQQ PALWPTLAAL ALLSSVAEAS LGSAPRSPAP REGPPPVLAS
    61  PAGHLPGGRT ARWCSGRARR PPPQPSRPAP PPPAPPSALP RGGRAARAGG PGSRARAAGA
   121  RGCRLRSQLV PVRALGLGHR SDELVRFRFC SGSCRRARSP HDLSLASLLG AGALRPPPGS
   181  RPVSQPCCRP TRYEAVSFMD VNSTWRTVDR LSATACGCLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

7.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0.36

gnomAD missense Z

1.22

DepMap mean gene effect

-0.24

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon guidance
• glial cell-derived neurotrophic factor receptor signaling pathway
• induction of positive chemotaxis
• lymphocyte migration into lymphoid organs
• neuroblast proliferation
• peripheral nervous system development
• Peyer's patch morphogenesis
• signal transduction

Molecular functions

• glial cell-derived neurotrophic factor receptor binding
• growth factor activity
• receptor tyrosine kinase binding
• signaling receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Transforming growth factor-beta, C-terminal
• Cystine-knot cytokine
• Glial cell line-derived neurotrophic factor family
• Transforming growth factor beta like domain

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ARTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GFRA3