Protease Inhibitors and Growth Factor Antagonists
IPR050653
Definition
The protein family encompasses a group of secreted proteins that play diverse roles in physiological processes such as inhibition of proteases, antagonism of growth factors, and regulation of cell proliferation, differentiation, and immune responses. Members of the family are known to interact with and inhibit various proteases like subtilisin-like serine proteases and trypsin, as well as growth factors such as activin and TGF-beta family members. They are involved in defense mechanisms between plants and pathogens, neural induction, angiogenesis, and hematopoiesis. Some members also possess neurotoxic properties by inhibiting ion channels. The family includes proteins with kazal serine protease inhibitor signatures and those that bind directly to activin, functioning as activin antagonists, thereby regulating the biosynthesis and secretion of hormones like FSH.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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