Seroatlas · Human Serome Atlas

FIRRM

FIGNL1-interacting regulator of recombination and mitosis

Also known as: C1orf112, FIRRM_HUMAN, FLJ10706

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSG2
Gene
FIRRM
Ensembl
ENSG00000000460
Chromosome
1
Canonical length
853 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including midbody; nuclear lumen; and spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

853 residues, UniProt reviewed canonical sequence.

>Q9NSG2|FIRRM
     1  MFLPHMNHLT LEQTFFSQVL PKTVKLFDDM MYELTSQARG LSSQNLEIQT TLRNILQTMV
    61  QLLGALTGCV QHICATQESI ILENIQSLPS SVLHIIKSTF VHCKNSESVY SGCLHLVSDL
   121  LQALFKEAYS LQKQLMELLD MVCMDPLVDD NDDILNMVIV IHSLLDICSV ISSMDHAFHA
   181  NTWKFIIKQS LKHQSIIKSQ LKHKDIITSL CEDILFSFHS CLQLAEQMTQ SDAQDNADYR
   241  LFQKTLKLCR FFANSLLHYA KEFLPFLSDS CCTLHQLYLQ IHSKFPPSLY ATRISKAHQE
   301  EIAGAFLVTL DPLISQLLTF QPFMQVVLDS KLDLPCELQF PQCLLLVVVM DKLPSQPKEV
   361  QTLWCTDSQV SETTTRISLL KAVFYSFEQC SGELSLPVHL QGLKSKGKAE VAVTLYQHVC
   421  VHLCTFITSF HPSLFAELDA ALLNAVLSAN MITSLLAMDA WCFLARYGTA ELCAHHVTIV
   481  AHLIKSCPGE CYQLINLSIL LKRLFFFMAP PHQLEFIQKF SPKEAENLPL WQHISFQALP
   541  PELREQTVHE VTTVGTAECR KWLSRSRTLG ELESLNTVLS ALLAVCNSAG EALDTGKQTA
   601  IIEVVSQLWA FLNIKQVADQ PYVQQTFSLL LPLLGFFIQT LDPKLILQAV TLQTSLLKLE
   661  LPDYVRLAML DFVSSLGKLF IPEAIQDRIL PNLSCMFALL LADRSWLLEQ HTLEAFTQFA
   721  EGTNHEEIVP QCLSSEETKN KVVSFLEKTG FVDETEAAKV ERVKQEKGIF WEPFANVTVE
   781  EAKRSSLQPY AKRARQEFPW EEEYRSALHT IAGALEATES LLQKGPAPAW LSMEMEALQE
   841  RMDKLKRYIH TLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIRRM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 13 nTPM
  • thymus: 11 nTPM
  • testis: 9.6 nTPM
  • bone marrow: 8.5 nTPM
  • tonsil: 7.4 nTPM
  • lymph node: 5.9 nTPM

Single-cell type

  • cardiomyocytes: 89 nCPM
  • thymocytes: 84 nCPM
  • microglia: 78 nCPM
  • early primary spermatocytes: 78 nCPM
  • adipocytes: 63 nCPM
  • hematopoietic stem cells: 55 nCPM

Immune cell

  • non-classical monocyte: 2.4 nTPM
  • basophil: 2.2 nTPM
  • NK-cell: 2.2 nTPM
  • intermediate monocyte: 2 nTPM
  • memory B-cell: 1.4 nTPM
  • naive B-cell: 1.4 nTPM

Brain region

  • cerebellum: 4.7 nTPM
  • white matter: 4.2 nTPM
  • medulla oblongata: 3.3 nTPM
  • basal ganglia: 3 nTPM
  • thalamus: 3 nTPM
  • cerebral cortex: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4487
  • Domain of unknown function (DUF4487)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FIRRM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIRRM as an antibody target. Whether an autoantibody or antibody against FIRRM could matter depends on whether native FIRRM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIRRM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FIRRM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FIRRM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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