Seroatlas · Human Serome Atlas

SPIDR

DNA repair-scaffolding protein

Also known as: KIAA0146, SPIDR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14159
Gene
SPIDR
Ensembl
ENSG00000164808
Chromosome
8
Canonical length
915 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Located in nuclear chromosome and nucleoplasm. Implicated in ovarian dysgenesis 9. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

915 residues, UniProt reviewed canonical sequence.

>Q14159|SPIDR
     1  MPRGSRARGS KRKRSWNTEC PSFPGERPLQ VRRAGLRTAG AAASLSEAWL RCGEGFQNTS
    61  GNPSLTAEEK TITEKHLELC PRPKQETTTS KSTSGLTDIT WSSSGSDLSD EDKTLSQLQR
   121  DELQFIDWEI DSDRAEASDC DEFEDDEGAV EISDCASCAS NQSLTSDEKL SELPKPSSIE
   181  ILEYSSDSEK EDDLENVLLI DSESPHKYHV QFASDARQIM ERLIDPRTKS TETILHTPQK
   241  PTAKFPRTPE NSAKKKLLRG GLAERLNGLQ NRERSAISLW RHQCISYQKT LSGRKSGVLT
   301  VKILELHEEC AMQVAMCEQL LGSPATSSSQ SVAPRPGAGL KVLFTKETAG YLRGRPQDTV
   361  RIFPPWQKLI IPSGSCPVIL NTYFCEKVVA KEDSEKTCEV YCPDIPLPRR SISLAQMFVI
   421  KGLTNNSPEI QVVCSGVATT GTAWTHGHKE AKQRIPTSTP LRDSLLDVVE SQGAASWPGA
   481  GVRVVVQRVY SLPSRDSTRG QQGASSGHTD PAGTRACLLV QDACGMFGEV HLEFTMSKAR
   541  QLEGKSCSLV GMKVLQKVTR GRTAGIFSLI DTLWPPAIPL KTPGRDQPCE EIKTHLPPPA
   601  LCYILTAHPN LGQIDIIDED PIYKLYQPPV TRCLRDILQM NDLGTRCSFY ATVIYQKPQL
   661  KSLLLLEQRE IWLLVTDVTL QTKEERDPRL PKTLLVYVAP LCVLGSEVLE ALAGAAPHSL
   721  FFKDALRDQG RIVCAERTVL LLQKPLLSVV SGASSCELPG PVMLDSLDSA TPVNSICSVQ
   781  GTVVGVDEST AFSWPVCDMC GNGRLEQRPE DRGAFSCGDC SRVVTSPVLK RHLQVFLDCR
   841  SRPQCRVKVK LLQRSISSLL RFAAGEDGSY EVKSVLGKEV GLLNCFVQSV TAHPTSCIGL
   901  EEIELLSAGG ASAEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIDR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 26 nTPM
  • ovary: 25 nTPM
  • cerebellum: 23 nTPM
  • adipose tissue: 22 nTPM
  • esophagus: 22 nTPM
  • blood vessel: 20 nTPM

Single-cell type

  • epicardial cells: 780 nCPM
  • monocytes: 755 nCPM
  • neutrophils: 731 nCPM
  • alveolar cells type 2: 687 nCPM
  • transitional alveolar cells: 663 nCPM
  • corticotrophs: 656 nCPM

Immune cell

  • classical monocyte: 11 nTPM
  • MAIT T-cell: 9.4 nTPM
  • gdT-cell: 9.3 nTPM
  • T-reg: 8.9 nTPM
  • myeloid DC: 8.7 nTPM
  • NK-cell: 8 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 34 nTPM
  • amygdala: 31 nTPM
  • hippocampal formation: 31 nTPM
  • medulla oblongata: 30 nTPM
  • pons: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPIDR.

Disease | AllUniProt

Conditions SPIDR is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 184 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Domain of unknown function DUF4502
  • Domain of unknown function DUF4503
  • DNA repair-scaffolding protein
  • Domain of unknown function (DUF4502)
  • Domain of unknown function (DUF4503)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPIDR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIDR as an antibody target. Whether an autoantibody or antibody against SPIDR could matter depends on whether native SPIDR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIDR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPIDR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPIDR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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