FYVE, RhoGEF and PH domain-containing
IPR051092
Definition
The FYVE, RhoGEF and PH domain-containing protein family is involved in the regulation of the actin cytoskeleton and cell shape. Members of this family activate CDC42, a Ras-like Rho family GTPase, by facilitating the exchange of bound GDP for free GTP. This activation process is crucial for various cellular functions including the formation of filopodia and lamellipodia, cell polarity, cytokinesis, and potentially affects the lifespan of an organism. Some family members are also implicated in the activation of MAPK8 and may influence proangiogenic actions of VEGF in vascular endothelial cells. The family is characterized by the presence of multiple domains, including FYVE-type zinc fingers for endosomal localization, DH domains for interaction with GTPases, and PH domains for membrane association and lipid binding. These domains contribute to the diverse roles of the family in cellular signaling and morphology.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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