Seroatlas · Human Serome Atlas

UBAC2

Ubiquitin-associated domain-containing protein 2

Also known as: FLJ30548, PHGDHL1, RP11-178C10.1, UBAC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBM4
Gene
UBAC2
Ensembl
ENSG00000134882
Chromosome
13
Canonical length
344 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Acts upstream of or within protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q8NBM4|UBAC2
     1  MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQIWRLICG
    61  RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFLL IEAMQYFFGI
   121  TAASNLPSGF LAPVFALFVP FYCSIPRVQV AQILGPLSIT NKTLIYILGL QLFTSGSYIW
   181  IVAISGLMSG LCYDSKMFQV HQVLCIPSWM AKFFSWTLEP IFSSSEPTSE ARIGMGATLD
   241  IQRQQRMELL DRQLMFSQFA QGRRQRQQQG GMINWNRLFP PLRQRQNVNY QGGRQSEPAA
   301  PPLEVSEEQV ARLMEMGFSR GDALEALRAS NNDLNVATNF LLQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 37 nTPM
  • tongue: 36 nTPM
  • esophagus: 31 nTPM
  • skin: 30 nTPM
  • duodenum: 29 nTPM
  • parathyroid gland: 28 nTPM

Single-cell type

  • monocytes: 465 nCPM
  • myonuclei: 457 nCPM
  • esophageal apical cells: 375 nCPM
  • microglia: 352 nCPM
  • thymocytes: 330 nCPM
  • cardiomyocytes: 312 nCPM

Immune cell

  • total PBMC: 88 nTPM
  • MAIT T-cell: 87 nTPM
  • NK-cell: 85 nTPM
  • naive CD8 T-cell: 75 nTPM
  • naive CD4 T-cell: 74 nTPM
  • basophil: 65 nTPM

Brain region

  • thalamus: 28 nTPM
  • spinal cord: 26 nTPM
  • medulla oblongata: 24 nTPM
  • hippocampal formation: 22 nTPM
  • choroid plexus: 22 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.01
gnomAD missense Z
1.57
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBAC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBAC2 as an antibody target. Whether an autoantibody or antibody against UBAC2 could matter depends on whether native UBAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBAC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...