Seroatlas · Human Serome Atlas

ZFAND2B

AN1-type zinc finger protein 2B

Also known as: AIRAPL, ZFN2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV99
Gene: ZFAND2B
Ensembl: ENSG00000158552
Chromosome: 2
Canonical length: 257 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q8WV99|ZFAND2B
     1  MEFPDLGAHC SEPSCQRLDF LPLKCDACSG IFCADHVAYA QHHCGSAYQK DIQVPVCPLC
    61  NVPVPVARGE PPDRAVGEHI DRDCRSDPAQ QKRKIFTNKC ERAGCRQREM MKLTCERCSR
   121  NFCIKHRHPL DHDCSGEGHP TSRAGLAAIS RAQAVASTST VPSPSQTMPS CTSPSRATTR
   181  SPSWTAPPVI ALQNGLSEDE ALQRALEMSL AETKPQVPSC QEEEDLALAQ ALSASEAEYQ
   241  RQQAQSRSSK PSNCSLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

liver: 63 nTPM
thyroid gland: 47 nTPM
esophagus: 47 nTPM
spleen: 44 nTPM
small intestine: 43 nTPM
kidney: 42 nTPM

Single-cell type

esophageal apical cells: 291 nCPM
enterocytes: 159 nCPM
platelets: 146 nCPM
colonocytes: 116 nCPM
esophageal suprabasal cells: 97 nCPM
megakaryocytes: 80 nCPM

Immune cell

neutrophil: 59 nTPM
NK-cell: 54 nTPM
naive B-cell: 53 nTPM
T-reg: 52 nTPM
gdT-cell: 49 nTPM
naive CD8 T-cell: 49 nTPM

Brain region

medulla oblongata: 36 nTPM
white matter: 36 nTPM
cerebellum: 31 nTPM
pons: 30 nTPM
thalamus: 30 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFAND2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND2B as an antibody target. Whether an autoantibody or antibody against ZFAND2B could matter depends on whether native ZFAND2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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