Seroatlas · Human Serome Atlas

JMJD4

2-oxoglutarate and iron-dependent oxygenase JMJD4

Also known as: FLJ12517, JMJD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9V9
Gene
JMJD4
Ensembl
ENSG00000081692
Chromosome
1
Canonical length
417 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Enables peptidyl-lysine 4-dioxygenase activity. Involved in positive regulation of translational termination and protein hydroxylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q9H9V9|JMJD4
     1  MDRETRALAD SHFRGLGVDV PGVGQAPGRV AFVSEPGAFS YADFVRGFLL PNLPCVFSSA
    61  FTQGWGSRRR WVTPAGRPDF DHLLRTYGDV VVPVANCGVQ EYNSNPKEHM TLRDYITYWK
   121  EYIQAGYSSP RGCLYLKDWH LCRDFPVEDV FTLPVYFSSD WLNEFWDALD VDDYRFVYAG
   181  PAGSWSPFHA DIFRSFSWSV NVCGRKKWLL FPPGQEEALR DRHGNLPYDV TSPALCDTHL
   241  HPRNQLAGPP LEITQEAGEM VFVPSGWHHQ VHNLDDTISI NHNWVNGFNL ANMWRFLQQE
   301  LCAVQEEVSE WRDSMPDWHH HCQVIMRSCS GINFEEFYHF LKVIAEKRLL VLREAAAEDG
   361  AGLGFEQAAF DVGRITEVLA SLVAHPDFQR VDTSAFSPQP KELLQQLREA VDAAAAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JMJD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • adrenal gland: 16 nTPM
  • liver: 14 nTPM
  • pituitary gland: 12 nTPM
  • ovary: 11 nTPM
  • skeletal muscle: 11 nTPM

Single-cell type

  • late spermatids: 332 nCPM
  • late primary spermatocytes: 91 nCPM
  • epicardial cells: 84 nCPM
  • cardiomyocytes: 76 nCPM
  • early spermatids: 68 nCPM
  • breast lactating cells: 53 nCPM

Immune cell

  • NK-cell: 14 nTPM
  • plasmacytoid DC: 13 nTPM
  • naive CD4 T-cell: 13 nTPM
  • MAIT T-cell: 12 nTPM
  • naive CD8 T-cell: 11 nTPM
  • gdT-cell: 11 nTPM

Brain region

  • pons: 10 nTPM
  • midbrain: 9.8 nTPM
  • medulla oblongata: 9.4 nTPM
  • white matter: 9.1 nTPM
  • amygdala: 8.5 nTPM
  • thalamus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0
gnomAD missense Z
-0.84
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JMJD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JMJD4 as an antibody target. Whether an autoantibody or antibody against JMJD4 could matter depends on whether native JMJD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JMJD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JMJD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JMJD4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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