Seroatlas · Human Serome Atlas

EIF4E3

Eukaryotic translation initiation factor 4E type 3

Also known as: IF4E3_HUMAN, MGC39820

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5X7
Gene: EIF4E3
Ensembl: ENSG00000163412
Chromosome: 3
Canonical length: 224 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q8N5X7|EIF4E3
     1  MALPPAAAPP AGAREPPGSR AAAAAAAPEP PLGLQQLSAL QPEPGGVPLH SSWTFWLDRS
    61  LPGATAAECA SNLKKIYTVQ TVQIFWSVYN NIPPVTSLPL RCSYHLMRGE RRPLWEEESN
   121  AKGGVWKMKV PKDSTSTVWK ELLLATIGEQ FTDCAAADDE VIGVSVSVRD REDVVQVWNV
   181  NASLVGEATV LEKIYELLPH ITFKAVFYKP HEEHHAFEGG RGKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4E3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 58 nTPM
tongue: 51 nTPM
heart muscle: 28 nTPM
adipose tissue: 26 nTPM
bone marrow: 25 nTPM
parathyroid gland: 23 nTPM

Single-cell type

podocytes: 36 nCPM
distal convoluted tubule cells: 30 nCPM
renal connecting tubule cells: 29 nCPM
loop of henle epithelial cells: 26 nCPM
papillary tip epithelial cells: 19 nCPM
proximal tubule cells: 19 nCPM

Immune cell

neutrophil: 15 nTPM
eosinophil: 6.1 nTPM
T-reg: 5.7 nTPM
classical monocyte: 4.2 nTPM
memory CD8 T-cell: 3.5 nTPM
MAIT T-cell: 3.2 nTPM

Brain region

cerebral cortex: 55 nTPM
hippocampal formation: 53 nTPM
basal ganglia: 52 nTPM
hypothalamus: 49 nTPM
white matter: 47 nTPM
amygdala: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.02
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4E3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4E3 as an antibody target. Whether an autoantibody or antibody against EIF4E3 could matter depends on whether native EIF4E3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4E3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4E3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...