Seroatlas · Human Serome Atlas

DELE1

DAP3-binding cell death enhancer 1

Also known as: DELE, DELE1_HUMAN, KIAA0141

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14154
Gene
DELE1
Ensembl
ENSG00000081791
Chromosome
5
Canonical length
515 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus
Quaternary structure
Homooctamer

OverviewNCBI Gene

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including HRI-mediated signaling; positive regulation of mitophagy; and response to iron ion starvation. Located in mitochondrial inner membrane. Is active in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q14154|DELE1
     1  MWRLPGLLGR ALPRTLGPSL WRVTPKSTSP DGPQTTSSTL LVPVPNLDRS GPHGPGTSGG
    61  PRSHGWKDAF QWMSSRVSPN TLWDAISWGT LAVLALQLAR QIHFQASLPA GPQRVEHCSW
   121  HSPLDRFFSS PLWHPCSSLR QHILPSPDGP APRHTGLREP RLGQEEASAQ PRNFSHNSLR
   181  GARPQDPSEE GPGDFGFLHA SSSIESEAKP AQPQPTGEKE QDKSKTLSLE EAVTSIQQLF
   241  QLSVSIAFNF LGTENMKSGD HTAAFSYFQK AAARGYSKAQ YNAGLCHEHG RGTPRDISKA
   301  VLYYQLAASQ GHSLAQYRYA RCLLRDPASS WNPERQRAVS LLKQAADSGL REAQAFLGVL
   361  FTKEPYLDEQ RAVKYLWLAA NNGDSQSRYH LGICYEKGLG VQRNLGEALR CYQQSAALGN
   421  EAAQERLRAL FSMGAAAPGP SDLTVTGLKS FSSPSLCSLN TLLAGTSRLP HASSTGNLGL
   481  LCRSGHLGAS LEASSRAIPP HPYPLERSVV RLGFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DELE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 74 nTPM
  • skeletal muscle: 66 nTPM
  • spleen: 61 nTPM
  • cerebellum: 54 nTPM
  • adrenal gland: 51 nTPM
  • liver: 50 nTPM

Single-cell type

  • microglia: 77 nCPM
  • lymphatic endothelial cells: 63 nCPM
  • kupffer cells: 62 nCPM
  • hofbauer cells: 60 nCPM
  • vascular endothelial cells: 52 nCPM
  • lactotrophs: 51 nCPM

Immune cell

  • non-classical monocyte: 67 nTPM
  • intermediate monocyte: 57 nTPM
  • myeloid DC: 56 nTPM
  • classical monocyte: 43 nTPM
  • T-reg: 27 nTPM
  • total PBMC: 25 nTPM

Brain region

  • choroid plexus: 55 nTPM
  • cerebellum: 47 nTPM
  • thalamus: 47 nTPM
  • cerebral cortex: 46 nTPM
  • medulla oblongata: 46 nTPM
  • pons: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DELE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DELE1 as an antibody target. Whether an autoantibody or antibody against DELE1 could matter depends on whether native DELE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DELE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DELE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DELE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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