Seroatlas · Human Serome Atlas

DRD3

D(3) dopamine receptor

Also known as: DRD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35462
Gene
DRD3
Ensembl
ENSG00000151577
Chromosome
3
Canonical length
400 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>P35462|DRD3
     1  MASLSQLSGH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL
    61  QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN
   121  LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV
   181  CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ
   241  QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
   301  LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV
   361  SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
5.2 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 5.2 nTPM
  • testis: 0.6 nTPM
  • hypothalamus: 0.3 nTPM
  • midbrain: 0.1 nTPM
  • retina: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • late spermatids: 71 nCPM
  • early spermatids: 39 nCPM
  • brain inhibitory neurons: 26 nCPM
  • other brain neurons: 12 nCPM
  • brain excitatory neurons: 5.6 nCPM
  • cone photoreceptor cells: 4.1 nCPM

Immune cell

  • memory CD4 T-cell: 0.3 nTPM
  • T-reg: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • basal ganglia: 9.6 nTPM
  • hypothalamus: 7.8 nTPM
  • cerebral cortex: 2.2 nTPM
  • pons: 1.6 nTPM
  • hippocampal formation: 0.8 nTPM
  • midbrain: 0.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DRD3.

Disease | AllUniProt

Conditions DRD3 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
1.47
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRD3 as an antibody target. Whether an autoantibody or antibody against DRD3 could matter depends on whether native DRD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRD3 is annotated at the cell surface, where native DRD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DRD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DRD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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