Seroatlas · Human Serome Atlas

PALM

Paralemmin-1

Also known as: KIAA0270, PALM_HUMAN, PALM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75781
Gene
PALM
Ensembl
ENSG00000099864
Chromosome
19
Canonical length
387 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>O75781|PALM
     1  MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL RERWLLEGTP
    61  SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER GDSAPATAKE NAAAPSPVRA
   121  PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR VSNTPLRTVD GSPMMKAAMY SVEITVEKDK
   181  VTGETRVLSS TTLLPRQPLP LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD
   241  EVTLSEAGST AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM
   301  IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP PTEAASREEN
   361  QAGPEATTSD PQDLDMKKHR CKCCSIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
293 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 293 nTPM
  • cerebral cortex: 287 nTPM
  • hippocampal formation: 245 nTPM
  • basal ganglia: 222 nTPM
  • hypothalamus: 107 nTPM
  • midbrain: 107 nTPM

Single-cell type

  • astrocytes: 125 nCPM
  • lymphatic endothelial cells: 108 nCPM
  • müller glia: 98 nCPM
  • ependymal cells: 83 nCPM
  • fibro-adipogenic progenitors: 81 nCPM
  • leydig cells: 70 nCPM

Immune cell

  • non-classical monocyte: 1.9 nTPM
  • intermediate monocyte: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hippocampal formation: 271 nTPM
  • cerebral cortex: 262 nTPM
  • amygdala: 255 nTPM
  • basal ganglia: 218 nTPM
  • thalamus: 163 nTPM
  • medulla oblongata: 151 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.52
gnomAD missense Z
0.72
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PALM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALM as an antibody target. Whether an autoantibody or antibody against PALM could matter depends on whether native PALM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALM is annotated at the cell surface, where native PALM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PALM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PALM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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