Seroatlas · Human Serome Atlas

NRAP

Nebulin-related-anchoring protein

Also known as: NRAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VF7
Gene: NRAP
Ensembl: ENSG00000197893
Chromosome: 10
Canonical length: 1730 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens and muscle tendon junction. Predicted to be active in Z disc. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1730 residues, UniProt reviewed canonical sequence.

>Q86VF7|NRAP
     1  MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK
    61  NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH WDMKSKDKEG APNRQPLANE
   121  RAYWTGYGEG NAWCPGALPD PEIVRMVEAR KSLGEEYTED YEQPRGKGSF PAMITPAYQR
   181  AKKANQLASQ VEYKRGHDER ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS
   241  FPAMITPAYQ IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE
   301  EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL PAQDNLVLKQ
   361  AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS KFTSDNKYKE NYQNHMRGRY
   421  EGVGMDRRTL HAMKVGSLAS NVAYKADYKH DIVDYNYPAT LTPSYQTAMK LVPLKDANYR
   481  QSIDKLKYSS VTDTPQIVQA KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK
   541  LFSEVKYKEG WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS
   601  RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL DYRKKLHEYT
   661  VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS LNLEQAKKAG QLVSEKNYRQ
   721  RVDELKFTSV TDSSQMEHAK KSQELQSGVA YKAGNEQSVH QYTISKDEPL FLQARANAAN
   781  LSEKLYKSSW ENQKAKGFEL RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ
   841  GDSQMSHSLQ MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH
   901  HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK KAGELISEKK
   961  YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN IKHHYTPTAD LPEVLLAKLN
  1021  AMNISETRYK ESWSKLRDGG YKLRLDALPF QAAKASGEII SDYKYKEAFE KMKGQMLGSR
  1081  SLEDDISLAH SVYATSLQSD VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH
  1141  PLPQYTSLAE DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS
  1201  ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM TLGLPEFIRA
  1261  KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG DIASDFLYRH DFVKERGKLI
  1321  GPQSVRDDPR IQHCRRMGQL QSELQYRRGA TSSQAQFHLP MDMVHLVHAK NAQALASDHD
  1381  YRTQYHKFTA LPEDLKMAWA KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE
  1441  LISETKYRKK PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF
  1501  TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR YKEAFLRDRG
  1561  LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF HSSTDQPGLL QAKRSQQLAS
  1621  DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ SDVKYKSDLN LTRGVGWTPP GSYKVEMARR
  1681  AAELANARGL GLQGAYRGAE AVEAGDHQSG EVNPDATEIL HVKKKKALLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 2,213 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 2,213 nTPM
tongue: 1,070 nTPM
heart muscle: 395 nTPM
esophagus: 23 nTPM
salivary gland: 21 nTPM
prostate: 19 nTPM

Single-cell type

myonuclei: 1,072 nCPM
cardiomyocytes: 633 nCPM
thymic myoid cells: 426 nCPM
epicardial cells: 18 nCPM
myosatellite cells: 9.4 nCPM
oocytes: 9.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
basal ganglia: 0.7 nTPM
thalamus: 0.7 nTPM
midbrain: 0.5 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NRAP.

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 459 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiovascular phenotype
CARDIOMYOPATHY, DILATED, 2N
NRAP-related disorder
Primary dilated cardiomyopathy
Non-dilated left ventricular cardiomyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cardiac muscle thin filament assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRAP as an antibody target. Whether an autoantibody or antibody against NRAP could matter depends on whether native NRAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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