LDHD

Protein identityUniProt · HPA

UniProt accession

Q86WU2

Gene

LDHD

Ensembl

ENSG00000166816

Chromosome

16

Canonical length

507 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homooligomer

OverviewNCBI Gene

The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q86WU2|LDHD
     1  MARLLRSATW ELFPWRGYCS QKAKGELCRD FVEALKAVVG GSHVSTAAVV REQHGRDESV
    61  HRCEPPDAVV WPQNVEQVSR LAALCYRQGV PIIPFGTGTG LEGGVCAVQG GVCVNLTHMD
   121  RILELNQEDF SVVVEPGVTR KALNAHLRDS GLWFPVDPGA DASLCGMAAT GASGTNAVRY
   181  GTMRDNVLNL EVVLPDGRLL HTAGRGRHFR FGFWPEIPHH TAWYSPCVSL GRRKSAAGYN
   241  LTGLFVGSEG TLGLITATTL RLHPAPEATV AATCAFPSVQ AAVDSTVHIL QAAVPVARIE
   301  FLDEVMMDAC NRYSKLNCLV APTLFLEFHG SQQALEEQLQ RTEEIVQQNG ASDFSWAKEA
   361  EERSRLWTAR HNAWYAALAT RPGCKGYSTD VCVPISRLPE IVVQTKEDLN ASGLTGSIVG
   421  HVGDGNFHCI LLVNPDDAEE LGRVKAFAEQ LGRRALALHG TCTGEHGIGM GKRQLLQEEV
   481  GAVGVETMRQ LKAVLDPQGL MNPGKVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDHD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

126 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LDHD.

Disease | AllUniProt

Conditions LDHD is implicated in, by any mechanism.

• D-lactic aciduria with gout (DLACD) MIM:245450

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 120 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Lactic aciduria due to D-lactic acid
• Abnormal circulating lactate dehydrogenase concentration

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.43

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• lactate catabolic process

Molecular functions

• FAD binding
• flavin adenine dinucleotide binding
• (2R)-2-hydroxycarboxylate dehydrogenase activity
• D-lactate dehydrogenase (cytochrome) activity
• D-lactate dehydrogenase (FAD) activity
• D-lactate dehydrogenase (NAD+) activity
• lactate dehydrogenase activity

Cellular components

• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• FAD-binding oxidoreductase/transferase, type 4, C-terminal
• FAD linked oxidase, N-terminal
• FAD-linked oxidase-like, C-terminal
• FAD-binding domain, PCMH-type
• FAD-binding, type PCMH, subdomain 1
• FAD-binding, type PCMH, subdomain 2
• Vanillyl-alcohol oxidase, C-terminal subdomain 2
• FAD-binding, type PCMH-like superfamily
• FAD binding domain
• FAD linked oxidases, C-terminal domain

KeywordsUniProt

• Acetylation
• FAD
• Flavoprotein
• Manganese
• Metal-binding
• Mitochondrion
• Oxidoreductase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of LDHD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSRP3