Seroatlas · Human Serome Atlas

UCN

Urocortin

Also known as: UCN1, UCN1_HUMAN, UI, UROC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55089
Gene: UCN
Ensembl: ENSG00000163794
Chromosome: 2
Canonical length: 124 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles,Plasma membrane
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>P55089|UCN
     1  MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG ARALLLLLAE
    61  RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL ELARTQSQRE RAEQNRIIFD
   121  SVGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 9.2 nTPM
cerebral cortex: 8.6 nTPM
hippocampal formation: 8.4 nTPM
amygdala: 7.8 nTPM
hypothalamus: 6.8 nTPM
liver: 6 nTPM

Single-cell type

pancreatic acinar cells: 14 nCPM
cardiomyocytes: 9.4 nCPM
oligodendrocytes: 9.4 nCPM
brain inhibitory neurons: 9.2 nCPM
sertoli cells: 9 nCPM
astrocytes: 8.5 nCPM

Immune cell

NK-cell: 0.7 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

midbrain: 33 nTPM
pons: 26 nTPM
white matter: 15 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 13 nTPM
amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.45
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UCN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCN as an antibody target. Whether an autoantibody or antibody against UCN could matter depends on whether native UCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCN is annotated as secreted, so native UCN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...