Seroatlas · Human Serome Atlas

CPAMD8

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

Also known as: CPMD8_HUMAN, K-CAP, KIAA1283, VIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZJ3
Gene
CPAMD8
Ensembl
ENSG00000160111
Chromosome
19
Canonical length
1885 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Focal adhesion sites
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1885 residues, UniProt reviewed canonical sequence.

>Q8IZJ3|CPAMD8
     1  MSGALLWPLL PLLLLLLSAR DGVRAAQPQA PGYLIAAPSV FRAGVEEVIS VTIFNSPREV
    61  TVQAQLVAQG EPVVQSQGAI LDKGTIKLKV PTGLRGQALL KVWGRGWQAE EGPLFHNQTS
   121  VTVDGRGASV FIQTDKPVYR PQHRVLISIF TVSPNLRPVN EKLEAYILDP RGSRMIEWRH
   181  LKPFCCGITN MSFPLSDQPV LGEWFIFVEM QGHAYNKSFE VQKYVLPKFE LLIDPPRYIQ
   241  DLDACETGTV RARYTFGKPV AGALMINMTV NGVGYYSHEV GRPVLRTTKI LGSRDFDICV
   301  RDMIPADVPE HFRGRVSIWA MVTSVDGSQQ VAFDDSTPVQ RQLVDIRYSK DTRKQFKPGL
   361  AYVGKVELSY PDGSPAEGVT VQIKAELTPK DNIYTSEVVS QRGLVGFEIP SIPTSAQHVW
   421  LETKVMALNG KPVGAQYLPS YLSLGSWYSP SQCYLQLQPP SHPLQVGEEA YFSVKSTCPC
   481  NFTLYYEVAA RGNIVLSGQQ PAHTTQQRSK RAAPALEKPI RLTHLSETEP PPAPEAEVDV
   541  CVTSLHLAVT PSMVPLGRLL VFYVRENGEG VADSLQFAVE TFFENQVSVT YSANETQPGE
   601  VVDLRIRAAR GSCVCVAAVD KSVYLLRSGF RLTPAQVFQE LEDYDVSDSF GVSREDGPFW
   661  WAGLTAQRRR RSSVFPWPWG ITKDSGFAFT ETGLVVMTDR VSLNHRQDGG LYTDEAVPAF
   721  QPHTGSLVAV APSRHPPRTE KRKRTFFPET WIWHCLNISD PSGEGTLSVK VPDSITSWVG
   781  EAVALSTSQG LGIAEPSLLK TFKPFFVDFM LPALIIRGEQ VKIPLSVYNY MGTCAEVYMK
   841  LSVPKGIQFV GHPGKRHVTK KMCVAPGEAE PIWVVLSFSD LGLNNITAKA LAYGDTNCCR
   901  DGRSSKHPEE NHADRRVPIG VDHVRRSVMV EAEGVPRAYT YSAFFCPSER VHISTPNKYE
   961  FQYVQRPLRL TRFDVAVRAH NDARVALSSG PQDTAGMIEI VLGGHQNTRS WISTSKMGEP
  1021  VASAHTAKIL SWDEFRTFWI SWRGGLIQVG HGPEPSNESV IVAWTLPRPP EVQFIGFSTG
  1081  WGSMGEFRIW RKMEVDESYS EAFTLGVPHG AIPGSERATA SIIGDVMGPT LNHLNNLLRL
  1141  PFGCGEQNMI HFAPNVFVLK YLQKTQQLSP EVERETTDYL VQGYQRQLTY KRQDGSYSAF
  1201  GERDASGSMW LTAFVLKSFA QARSFIFVDP RELAAAKSWI IQQQQADGSF LAVGRVLNKD
  1261  IQGGIHGTVP LTAYVVVALL ETGTASEEER GSTDKARHFL ESAAPLAMDP YSCALTTYAL
  1321  TLLRSPAAPE ALRKLRSLAI MRDGVTHWSL SNSWDVDKGT FLSFSDRVSQ SVVSAEVEMT
  1381  AYALLTYTLL GDVAAALPVV KWLSQQRNAL GGFSSTQDTC VALQALAEYA ILSYAGGINL
  1441  TVSLASTNLD YQETFELHRT NQKVLQTAAI PSLPTGLFVS AKGDGCCLMQ IDVTYNVPDP
  1501  VAKPAFQLLV SLQEPEAQGR PPPMPASAAE GSRGDWPPAD DDDPAADQHH QEYKVMLEVC
  1561  TRWLHAGSSN MAVLEVPLLS GFRADIESLE QLLLDKHMGM KRYEVAGRRV LFYFDEIPSR
  1621  CLTCVRFRAL RECVVGRTSA LPVSVYDYYE PAFEATRFYN VSTHSPLARE LCAGPACNEV
  1681  ERAPARGPGW FPGESGPAVA PEEGAAIARC GCDHDCGAQG NPVCGSDGVV YASACRLREA
  1741  ACRQAAPLEP APPSCCALEQ RLPASSSSTY GDDLASVAPG PLQQDVKLNG AGLEVEDSDP
  1801  EPEGEAEDRV TAGPRPPVSS GNLESSTQSA SPFHRWGQTP APQRHSGRVV GAHRPGLLSP
  1861  VFVYSPAFQS GGEEGLWMSN TCTLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPAMD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 35 nTPM
  • prostate: 15 nTPM
  • epididymis: 14 nTPM
  • lung: 13 nTPM
  • heart muscle: 12 nTPM
  • thyroid gland: 11 nTPM

Single-cell type

  • ocular epithelial cells: 199 nCPM
  • prostatic glandular cells: 138 nCPM
  • renal collecting duct intercalated cells: 121 nCPM
  • renal collecting duct principal cells: 120 nCPM
  • epididymal principal cells: 120 nCPM
  • basal prostatic cells: 102 nCPM

Immune cell

  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • basophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 64 nTPM
  • white matter: 58 nTPM
  • midbrain: 56 nTPM
  • spinal cord: 45 nTPM
  • medulla oblongata: 43 nTPM
  • thalamus: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CPAMD8.

Disease | AllUniProt

Conditions CPAMD8 is implicated in, by any mechanism.

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 729 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on CPAMD8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
-0.34
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPAMD8 as an antibody target. Whether an autoantibody or antibody against CPAMD8 could matter depends on whether native CPAMD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPAMD8 is annotated at the cell surface, where native CPAMD8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPAMD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPAMD8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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