Collectin, C-type lectin-like domain
IPR033990
Definition
This entry represents the C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose-binding lectin (MBL, also known as mannan-binding protein or MBP), and CL-L1 (collectin liver 1) [[cite:PMID:16394659], [cite:PMID:8155265]]. CTLD refers to a domain, homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins PMID:16336259. The CTLDs of these collectins bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, or apoptotic cells) and mediate functions associated with killing and phagocytosis. MBPs recognize high mannose oligosaccharides in a calcium dependent manner, bind to a broad range of pathogens, and trigger cell killing by activating the complement pathway [[cite:PMID:12887296], [cite:PMID:11414367]]. MBP also acts directly as an opsonin PMID:2469767. SP-A and SP-D in addition to functioning as host defense components, are components of pulmonary surfactant which play a role in surfactant homeostasis [[cite:PMID:16213021], [cite:PMID:23441475]]. Pulmonary surfactant is a phospholipid-protein complex which reduces the surface tension within the lungs. SP-A binds the major surfactant lipid: dipalmitoylphosphatidylcholine (DPPC). SP-D binds two minor components of surfactant that contain sugar moieties: glucosylceramide and phosphatidylinositol (PI). MBP and SP-A, -D monomers are homotrimers with an N-terminal collagen region and three CTLDs. Multiple homotrimeric units associate to form supramolecular complexes. MBL deficiency results in an increased susceptibility to a large number of different infections and to inflammatory disease PMID:22377282.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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