Collagen superfamily
IPR050149
Definition
The collagen family is characterized by its role in providing structural integrity to various tissues. Collagens are major components of the extracellular matrix and are involved in the formation of fibrils and networks that support the architecture of tissues such as skin, bone, cartilage, and basement membranes. They contribute to the physical properties of tissues, including elasticity and strength. Collagens also play roles in tissue development, growth, and repair. Some family members have specialized functions, such as mediating cell attachment, influencing cell morphology, and participating in angiogenesis. Certain collagens interact with other matrix proteins, like laminins and proteoglycans, to form complex meshworks. Some collagen types are involved in defense mechanisms, as seen in viral surface structures or in lung defense against inhaled pathogens. The diversity of domains within collagen chains, including triple-helical and non-collagenous domains, allows for the formation of various supramolecular assemblies and the execution of distinct biological functions.
26 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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