Seroatlas · Human Serome Atlas

CNTD1

Cyclin N-terminal domain-containing protein 1

Also known as: CNTD, CNTD1_HUMAN, FLJ40137

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N815
Gene: CNTD1
Ensembl: ENSG00000176563
Chromosome: 17
Canonical length: 330 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be involved in reciprocal meiotic recombination and regulation of meiotic cell cycle. Predicted to act upstream of or within spermatogenesis. Predicted to be located in chromosome. Predicted to be active in site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q8N815|CNTD1
     1  MDGPMRPRSA SLVDFQFGVV ATETIEDALL HLAQQNEQAV REASGRLGRF REPQIVEFVF
    61  LLSEQWCLEK SVSYQAVEIL ERFMVKQAEN ICRQATIQPR DNKRESQNWR ALKQQLVNKF
   121  TLRLVSCVQL ASKLSFRNKI ISNITVLNFL QALGYLHTKE ELLESELDVL KSLNFRINLP
   181  TPLAYVETLL EVLGYNGCLV PAMRLHATCL TLLDLVYLLH EPIYESLLRA SIENSTPSQL
   241  QGEKFTSVKE DFMLLAVGII AASAFIQNHE CWSQVVGHLQ SITGIALASI AEFSYAILTH
   301  GVGANTPGRQ QSIPPHLAAR ALKTVASSNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

testis: 40 nTPM
stomach: 3.1 nTPM
breast: 1.7 nTPM
rectum: 1.7 nTPM
kidney: 1.4 nTPM
epididymis: 1.3 nTPM

Single-cell type

late primary spermatocytes: 181 nCPM
late spermatids: 174 nCPM
early primary spermatocytes: 160 nCPM
parietal cells: 111 nCPM
early spermatids: 61 nCPM
gastric chief cells: 56 nCPM

Immune cell

neutrophil: 0.4 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 3.8 nTPM
cerebral cortex: 2.9 nTPM
cerebellum: 2.5 nTPM
medulla oblongata: 2.4 nTPM
hypothalamus: 2.3 nTPM
midbrain: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNTD1 as an antibody target. Whether an autoantibody or antibody against CNTD1 could matter depends on whether native CNTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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