Seroatlas · Human Serome Atlas

PRR19

Proline-rich protein 19

Also known as: MGC70924, PRR19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJB7
Gene: PRR19
Ensembl: ENSG00000188368
Chromosome: 19
Canonical length: 356 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Nuclear bodies,Mitotic chromosome,Mitochondria

OverviewNCBI Gene

Predicted to be involved in meiotic cell cycle. Predicted to be located in chromosome and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>A6NJB7|PRR19
     1  MDTQGPVSQP FQQPEKPGRV RRRKTRRERN KALVGSRRPL AHHDPPVAIR DPPVVPTASK
    61  LVVITQGRLS REHRGLFNHE VKSLDVARLL SSGTLVPGSP TLPAKPSPSP GRAQEPAPRS
   121  RDKENQVPGG SGPGPPSSPE LSGVGQLLAE LQCQLSLPQA FPRRNLIQDA RDAIVHTLQA
   181  CHGCVPDLAL VLRGCQPPLP GAKPGVSERK MTPFWINSPD QVPEQERQRK QQGTKEFTFP
   241  MPYTSSMPTA HRGSLAPPRG PWPPYFPSLS SPSGTAWGPP TAFDLLKSIW LVATPPPPRP
   301  WGVGLPQPLP QPSSPLLPRT SVLDWSPSPP SPLPSLSWVV AQSSPEAWSF PPMRLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
basal ganglia: 4.3 nTPM
cerebral cortex: 2.3 nTPM
amygdala: 2.2 nTPM
cerebellum: 2.2 nTPM
bone marrow: 2.1 nTPM

Single-cell type

late spermatids: 102 nCPM
late primary spermatocytes: 40 nCPM
early primary spermatocytes: 31 nCPM
differentiating spermatogonia: 29 nCPM
early spermatids: 28 nCPM
paneth cells: 12 nCPM

Immune cell

memory B-cell: 0.5 nTPM
myeloid DC: 0.5 nTPM
T-reg: 0.5 nTPM
gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM

Brain region

basal ganglia: 5.9 nTPM
cerebral cortex: 5.6 nTPM
amygdala: 4.7 nTPM
hippocampal formation: 4.7 nTPM
hypothalamus: 4.7 nTPM
cerebellum: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.81
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

meiotic cell cycle

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proline-rich protein 19
Proline-rich 19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRR19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CNTD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR19 as an antibody target. Whether an autoantibody or antibody against PRR19 could matter depends on whether native PRR19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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