Seroatlas · Human Serome Atlas

QRICH2

Glutamine-rich protein 2

Also known as: DKFZP434P0316, QRIC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0J4
Gene: QRICH2
Ensembl: ENSG00000129646
Chromosome: 17
Canonical length: 1663 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

Involved in cell projection assembly; flagellated sperm motility; and negative regulation of ubiquitin-dependent protein catabolic process. Located in sperm flagellum. Implicated in spermatogenic failure 35. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1663 residues, UniProt reviewed canonical sequence.

>Q9H0J4|QRICH2
     1  MKDAAEELSF ARVLLQRVDE LEKLFKDREQ FLELVSRKLS LVPGAEEVTM VTWEELEQAI
    61  TDGWRASQAG SETLMGFSKH GGFTSLTSPE GTLSGDSTKQ PSIEQALDSA SGLGPDRTAS
   121  GSGGTAHPSD GVSSREQSKV PSGTGRQQQP RARDEAGVPR LHQSSTFQFK SDSDRHRSRE
   181  KLTSTQPRRN ARPGPVQQDL PLARDQPSSV PASQSQVHLR PDRRGLEPTG MNQPGLVPAS
   241  TYPHGVVPLS MGQLGVPPPE MDDRELIPFV VDEQRMLPPS VPGRDQQGLE LPSTDQHGLV
   301  SVSAYQHGMT FPGTDQRSME PLGMDQRGCV ISGMGQQGLV PPGIDQQGLT LPVVDQHGLV
   361  LPFTDQHGLV SPGLMPISAD QQGFVQPSLE ATGFIQPGTE QHDLIQSGRF QRALVQRGAY
   421  QPGLVQPGAD QRGLVRPGMD QSGLAQPGAD QRGLVWPGMD QSGLAQPGRD QHGLIQPGTG
   481  QHDLVQSGTG QGVLVQPGVD QPGMVQPGRF QRALVQPGAY QPGLVQPGAD QIDVVQPGAD
   541  QHGLVQSGAD QSDLAQPGAV QHGLVQPGVD QRGLAQPRAD HQRGLVPPGA DQRGLVQPGA
   601  DQHGLVQPGV DQHGLAQPGE VQRSLVQPGI VQRGLVQPGA VQRGLVQPGA VQRGLVQPGV
   661  DQRGLVQPGA VQRGLVQPGA VQHGLVQPGA DQRGLVQPGV DQRGLVQPGV DQRGLVQPGM
   721  DQRGLIQPGA DQPGLVQPGA GQLGMVQPGI GQQGMVQPQA DPHGLVQPGA YPLGLVQPGA
   781  YLHDLSQSGT YPRGLVQPGM DQYGLRQPGA YQPGLIAPGT KLRGSSTFQA DSTGFISVRP
   841  YQHGMVPPGR EQYGQVSPLL ASQGLASPGI DRRSLVPPET YQQGLMHPGT DQHSPIPLST
   901  GLGSTHPDQQ HVASPGPGEH DQVYPDAAQH GHAFSLFDSH DSMYPGYRGP GYLSADQHGQ
   961  EGLDPNRTRA SDRHGIPAQK APGQDVTLFR SPDSVDRVLS EGSEVSSEVL SERRNSLRRM
  1021  SSSFPTAVET FHLMGELSSL YVGLKESMKD LDEEQAGQTD LEKIQFLLAQ MVKRTIPPEL
  1081  QEQLKTVKTL AKEVWQEKAK VERLQRILEG EGNQEAGKEL KAGELRLQLG VLRVTVADIE
  1141  KELAELRESQ DRGKAAMENS VSEASLYLQD QLDKLRMIIE SMLTSSSTLL SMSMAPHKAH
  1201  TLAPGQIDPE ATCPACSLDV SHQVSTLVRR YEQLQDMVNS LAVSRPSKKA KLQRQDEELL
  1261  GRVQSAILQV QGDCEKLNIT TSNLIEDHRQ KQKDIAMLYQ GLEKLEKEKA NREHLEMEID
  1321  VKADKSALAT KVSRVQFDAT TEQLNHMMQE LVAKMSGQEQ DWQKMLDRLL TEMDNKLDRL
  1381  ELDPVKQLLE DRWKSLRQQL RERPPLYQAD EAAAMRRQLL AHFHCLSCDR PLETPVTGHA
  1441  IPVTPAGPGL PGHHSIRPYT VFELEQVRQH SRNLKLGSAF PRGDLAQMEQ SVGRLRSMHS
  1501  KMLMNIEKVQ IHFGGSTKAS SQIIRELLHA QCLGSPCYKR VTDMADYTYS TVPRRCGGSH
  1561  TLTYPYHRSR PQHLPRGLYP TEEIQIAMKH DEVDILGLDG HIYKGRMDTR LPGILRKDSS
  1621  GTSKRKSQQP RPHVHRPPSL SSNGQLPSRP QSAQISAGNT SER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QRICH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
cerebellum: 7.9 nTPM
thyroid gland: 5 nTPM
basal ganglia: 3.9 nTPM
cerebral cortex: 3.9 nTPM
hypothalamus: 3.9 nTPM

Single-cell type

early spermatids: 53 nCPM
late primary spermatocytes: 28 nCPM
choroid plexus epithelial cells: 20 nCPM
sertoli cells: 19 nCPM
salivary acinar cells: 19 nCPM
cardiomyocytes: 18 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 13 nTPM
cerebellum: 13 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 10 nTPM
thalamus: 8.9 nTPM
white matter: 8.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QRICH2.

Disease | AllUniProt

Conditions QRICH2 is implicated in, by any mechanism.

Spermatogenic failure 35 (SPGF35) MIM:618341

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 375 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 35
QRICH2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of QRICH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QRICH2 as an antibody target. Whether an autoantibody or antibody against QRICH2 could matter depends on whether native QRICH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QRICH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QRICH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...