Seroatlas · Human Serome Atlas

CEP170B

Centrosomal protein of 170 kDa protein B

Also known as: C170B_HUMAN, Cep170R, FAM68C, KIAA0284

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4F5
Gene: CEP170B
Ensembl: ENSG00000099814
Chromosome: 14
Canonical length: 1589 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubule ends,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1589 residues, UniProt reviewed canonical sequence.

>Q9Y4F5|CEP170B
     1  MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ DRDEHWVKDL
    61  GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER VQHRVPEEAL KHEKYTSQLQ
   121  VSVKGLAPKR SEALPEHTPY CEASNPRPEK GDRRPGTEAA SYRTPLYGQP SWWGEDDGST
   181  LPDAQRQGEP YPERPKGPVQ QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP
   241  EVPAHEMPTK DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK
   301  EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK GHKHEDGTQS
   361  DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN QQAFVIEFFD EDTPRKKRSQ
   421  SFTHSPSGDP KADKRRGPTP ADRDRPSVPA PVQAGGRSSG PQRAGSLKRE KTEERLGSPS
   481  PASRTPARPF GSVGRRSRLA QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP
   541  PTPPPAPTDP QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL
   601  SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL PVPGSPGGQK
   661  WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR LPQLPSERAD SPAGPESSRR
   721  SGPGPPELDS EQPSRLFGQE ELDPDSLSDA SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS
   781  RGRRSPRAPG EPTPASFFIG DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA
   841  NGRMVIQLRP GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA
   901  ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL SGDSDVDTAS
   961  TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL VSAREQSSER QHHPLGPTDM
  1021  GRGEPVRRSA IRRGHRPRGS LDWPSEERGP VLAHLPSSDV MASNHETPEA TGAGRLGSRR
  1081  KPAAPPPSPA AREEQSRSSA SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA
  1141  DGERGSLGNP EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV
  1201  ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR RQQGSDYTST
  1261  SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG PRDTDDDEEE PDPYGFIVQT
  1321  AEIAEIARLS QTLVKDVAIL AQEIHDVAGD GDTLGSSEPA HSASLSNMPS TPASTISARE
  1381  ELVQRIPEAS LNFQKVPPGS LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV
  1441  SQLSQAIREN TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR
  1501  RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA SAEALLPALP
  1561  LRNFPQRASC GPPSLPDPTF LPDAERFLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP170B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 47 nTPM
cerebral cortex: 42 nTPM
skin: 34 nTPM
esophagus: 30 nTPM
pancreas: 27 nTPM
amygdala: 26 nTPM

Single-cell type

cone photoreceptor cells: 114 nCPM
tuft cells: 58 nCPM
colonocytes: 57 nCPM
rod photoreceptor cells: 54 nCPM
esophageal apical cells: 51 nCPM
foveolar cells: 44 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 134 nTPM
hippocampal formation: 111 nTPM
amygdala: 104 nTPM
pons: 101 nTPM
white matter: 96 nTPM
basal ganglia: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

microtubule

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP170B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP170B as an antibody target. Whether an autoantibody or antibody against CEP170B could matter depends on whether native CEP170B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP170B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP170B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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