Seroatlas · Human Serome Atlas

BLK

Tyrosine-protein kinase Blk

Also known as: BLK_HUMAN, MGC10442

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51451
Gene: BLK
Ensembl: ENSG00000136573
Chromosome: 8
Canonical length: 505 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>P51451|BLK
     1  MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK
    61  HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE
   121  MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR
   181  CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS
   241  LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY
   301  AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD
   361  LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS
   421  FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER
   481  PTFEFLQSVL EDFYTATERQ YELQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

spleen: 50 nTPM
small intestine: 40 nTPM
lymph node: 27 nTPM
tonsil: 26 nTPM
appendix: 8 nTPM
colon: 3 nTPM

Single-cell type

b-cells: 166 nCPM
plasma cells: 11 nCPM
pdcs: 6.4 nCPM
oocytes: 4.6 nCPM
foveolar cells: 4.5 nCPM
thymocytes: 3.4 nCPM

Immune cell

memory B-cell: 168 nTPM
naive B-cell: 118 nTPM
MAIT T-cell: 35 nTPM
plasmacytoid DC: 16 nTPM
total PBMC: 8.2 nTPM
memory CD8 T-cell: 4.2 nTPM

Brain region

medulla oblongata: 0.2 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BLK.

Disease | AllUniProt

Conditions BLK is implicated in, by any mechanism.

Maturity-onset diabetes of the young 11 (MODY11) MIM:613375

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 437 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Systemic lupus erythematosus
Maturity-onset diabetes of the young type 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -1.88
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BLK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLK as an antibody target. Whether an autoantibody or antibody against BLK could matter depends on whether native BLK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLK is annotated at the cell surface, where native BLK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BLK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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