Seroatlas · Human Serome Atlas

SSU72

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Also known as: HSPC182, SSU72_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP77
Gene: SSU72
Ensembl: ENSG00000160075
Chromosome: 1
Canonical length: 194 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q9NP77|SSU72
     1  MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT
    61  YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV
   121  EDLNSREQET CQPVHVVNVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE
   181  EKSGRTFLHT VCFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSU72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 238 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 238 nTPM
tongue: 127 nTPM
choroid plexus: 125 nTPM
heart muscle: 125 nTPM
basal ganglia: 124 nTPM
esophagus: 119 nTPM

Single-cell type

late spermatids: 1,131 nCPM
esophageal apical cells: 822 nCPM
esophageal suprabasal cells: 443 nCPM
extravillous trophoblasts: 302 nCPM
early spermatids: 295 nCPM
esophageal basal cells: 285 nCPM

Immune cell

neutrophil: 205 nTPM
eosinophil: 189 nTPM
T-reg: 162 nTPM
basophil: 145 nTPM
naive CD4 T-cell: 128 nTPM
memory B-cell: 121 nTPM

Brain region

hypothalamus: 110 nTPM
choroid plexus: 109 nTPM
pons: 103 nTPM
midbrain: 97 nTPM
medulla oblongata: 97 nTPM
basal ganglia: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.78
gnomAD missense Z: 2.56
DepMap mean gene effect: -1.48
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA polymerase II CTD heptapeptide repeat phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSU72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSU72 as an antibody target. Whether an autoantibody or antibody against SSU72 could matter depends on whether native SSU72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSU72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSU72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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