CD109

Protein identityUniProt · HPA

UniProt accession

Q6YHK3

Gene

CD109

Ensembl

ENSG00000156535

Chromosome

6

Canonical length

1445 aa

Protein class

CD markers, Plasma proteins, Predicted membrane proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

1445 residues, UniProt reviewed canonical sequence.

>Q6YHK3|CD109
     1  MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA
    61  ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST
   121  RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL
   181  SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS
   241  MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
   301  NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL
   361  KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY
   421  TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG
   481  SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG
   541  EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
   601  ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY
   661  AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW
   721  VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV
   781  KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT
   841  ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
   901  GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG
   961  YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH
  1021  QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS
  1081  RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL
  1141  DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
  1201  ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV
  1261  YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL
  1321  LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS
  1381  IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF
  1441  MELWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD109 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

311 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD109.

Disease | ImmuneIEDB

Conditions an epitope on CD109 was assayed in.

• viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.19

gnomAD pLI

0

gnomAD missense Z

-0.5

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• hair follicle development
• keratinocyte proliferation
• negative regulation of keratinocyte proliferation
• negative regulation of stem cell proliferation
• negative regulation of transforming growth factor beta receptor signaling pathway
• negative regulation of wound healing
• osteoclast fusion
• regulation of keratinocyte differentiation
• stem cell proliferation

Molecular functions

• serine-type endopeptidase inhibitor activity

Cellular components

• cell surface
• cytosol
• extracellular region
• extracellular space
• plasma membrane
• platelet alpha granule membrane
• side of membrane

Protein domainsUniProt · Pfam · InterPro

• Alpha-2-macroglobulin
• Macroglobulin domain
• Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
• Alpha-macroglobulin, receptor-binding
• Alpha-2-macroglobulin, bait region domain
• Alpha-macroglobulin-like, TED domain
• Immunoglobulin-like fold
• Immunoglobulin E-set
• Alpha-2-macroglobulin, conserved site
• Alpha-macroglobulin, receptor-binding domain superfamily
• Macroglobulin domain MG3
• Alpha-2-macroglobulin, TED domain
• Alpha-macroglobulin-like, thiol-ester bond-forming region
• Alpha-2-macroglobulin/Complement system
• Alpha-2-macroglobulin family
• MG2 domain
• A-macroglobulin receptor binding domain
• A-macroglobulin TED domain
• Alpha-2-macroglobulin bait region domain
• Macroglobulin domain MG3

KeywordsUniProt

• Bait region
• Cell membrane
• Disulfide bond
• Glycoprotein
• GPI-anchor
• Lipoprotein
• Membrane
• Protease inhibitor
• Serine protease inhibitor
• Signal
• Thioester bond

InteractionsUniProt · HPA

Protein binding partners of CD109 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TGFB1
• TGFBR1