CAMK2B

Protein identityUniProt · HPA

UniProt accession

Q13554

Gene

CAMK2B

Ensembl

ENSG00000058404

Chromosome

7

Canonical length

666 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane,Cell Junctions,Primary cilium tip,Primary cilium transition zone,Perinuclear theca,Calyx,Connecting piece,Principal piece,End piece

OverviewNCBI Gene

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q13554|CAMK2B
     1  MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER
    61  EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI
   121  LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY
   181  LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT
   241  VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
   301  KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK
   361  NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR
   421  RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP
   481  ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK
   541  TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
   601  TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA
   661  PVAPLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMK2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

112 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMK2B.

Disease | AllUniProt

Conditions CAMK2B is implicated in, by any mechanism.

• Intellectual developmental disorder, autosomal dominant 54 (MRD54) MIM:617799

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 940 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability, autosomal dominant 54
• Intellectual disability
• Inborn genetic diseases
• 6 conditions
• Abnormality of the nervous system

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.74

gnomAD missense Z

4.07

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• long-term synaptic potentiation
• nervous system development
• positive regulation of dendritic spine morphogenesis
• positive regulation of neuron projection development
• positive regulation of synapse maturation
• protein autophosphorylation
• protein phosphorylation
• regulation of calcium ion transport
• regulation of dendritic spine development
• regulation of long-term neuronal synaptic plasticity
• regulation of neuron migration
• regulation of neuronal synaptic plasticity
• regulation of protein localization to plasma membrane
• regulation of skeletal muscle adaptation
• regulation of synapse structural plasticity
• signal transduction

Molecular functions

• actin binding
• ATP binding
• calcium/calmodulin-dependent protein kinase activity
• calmodulin binding
• identical protein binding
• protein homodimerization activity
• protein serine kinase activity

Cellular components

• calcium- and calmodulin-dependent protein kinase complex
• centrosome
• cytoplasm
• cytosol
• endocytic vesicle membrane
• neuron projection
• nucleoplasm
• postsynaptic density
• sarcoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Calcium/calmodulin-dependent protein kinase II, association-domain
• Protein kinase, ATP binding site
• NTF2-like domain superfamily
• Protein kinase domain
• Calcium/calmodulin dependent protein kinase II association domain

KeywordsUniProt

• Actin-binding
• ATP-binding
• Calmodulin-binding
• Cytoplasm
• Cytoskeleton
• Developmental protein
• Differentiation
• Intellectual disability
• Kinase
• Membrane
• Neurogenesis
• Nucleotide-binding
• Phosphoprotein
• Sarcoplasmic reticulum
• Serine/threonine-protein kinase
• Synapse
• Transferase

InteractionsUniProt · HPA

Protein binding partners of CAMK2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAMK2N1
• CAMK2N2
• FOXO3
• MPDZ
• SYNGAP1
• ARC
• AP5B1
• CAMK2A
• CAMK2D
• PHKB