CAMK2N2
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Also known as: CaM-KIIN, CK2N2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96S95
- Gene
- CAMK2N2
- Ensembl
- ENSG00000163888
- Chromosome
- 3
- Canonical length
- 79 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome,Basal body
OverviewNCBI Gene
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
79 residues, UniProt reviewed canonical sequence.
>Q96S95|CAMK2N2
1 MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ IGRAKRVVIE
61 DDRIDDVLKG MGEKPPSGVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CAMK2N2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- hypothalamus: 89 nTPM
- cerebellum: 81 nTPM
- amygdala: 64 nTPM
- cerebral cortex: 52 nTPM
- midbrain: 44 nTPM
- pituitary gland: 36 nTPM
Single-cell type
- other brain neurons: 96 nCPM
- pancreatic acinar cells: 58 nCPM
- brain inhibitory neurons: 54 nCPM
- retinal amacrine cells: 53 nCPM
- retinal horizontal cells: 50 nCPM
- brain excitatory neurons: 50 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 224 nTPM
- medulla oblongata: 209 nTPM
- pons: 176 nTPM
- midbrain: 159 nTPM
- hypothalamus: 153 nTPM
- amygdala: 133 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.57
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CAMK2N2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CAMK2N2 as an antibody target. Whether an autoantibody or antibody against CAMK2N2 could matter depends on whether native CAMK2N2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CAMK2N2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CAMK2N2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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