CAMK2N1
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Also known as: CaMKIINalpha, CK2N1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z7J9
- Gene
- CAMK2N1
- Ensembl
- ENSG00000162545
- Chromosome
- 1
- Canonical length
- 78 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Primary cilium,Cytosol
OverviewNCBI Gene
Predicted to enable calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Predicted to be involved in long-term memory and positive regulation of inflammatory response. Predicted to be located in neuronal cell body and synapse. Implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Biomarker of hepatocellular carcinoma; oral squamous cell carcinoma; papillary thyroid carcinoma; and prostate cancer. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
78 residues, UniProt reviewed canonical sequence.
>Q7Z7J9|CAMK2N1
1 MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ NKRPPKLGQI GRSKRVVIED
61 DRIDDVLKNM TDKAPPGVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CAMK2N1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 582 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 582 nTPM
- amygdala: 570 nTPM
- hippocampal formation: 353 nTPM
- basal ganglia: 203 nTPM
- midbrain: 199 nTPM
- hypothalamus: 175 nTPM
Single-cell type
- epididymal clear cells: 529 nCPM
- colonocytes: 496 nCPM
- salivary duct cells: 470 nCPM
- goblet cells: 465 nCPM
- esophageal apical cells: 361 nCPM
- epididymal efferent duct absorptive cells: 300 nCPM
Immune cell
- gdT-cell: 1.6 nTPM
- MAIT T-cell: 1.1 nTPM
- memory B-cell: 0.5 nTPM
- memory CD4 T-cell: 0.5 nTPM
- memory CD8 T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.4 nTPM
Brain region
- cerebral cortex: 749 nTPM
- white matter: 514 nTPM
- amygdala: 501 nTPM
- basal ganglia: 456 nTPM
- hippocampal formation: 439 nTPM
- thalamus: 347 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0.17
- gnomAD missense Z
- 1.44
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CAMK2N1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CAMK2N1 as an antibody target. Whether an autoantibody or antibody against CAMK2N1 could matter depends on whether native CAMK2N1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CAMK2N1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CAMK2N1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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