Seroatlas · Human Serome Atlas

SDE2

Splicing regulator SDE2

Also known as: C1orf55, FLJ35382, SDE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IQ49
Gene
SDE2
Ensembl
ENSG00000143751
Chromosome
1
Canonical length
451 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables damaged DNA binding activity and snoRNA binding activity. Involved in several processes, including cellular response to UV; gene expression; and mitotic G1 DNA damage checkpoint signaling. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q6IQ49|SDE2
     1  MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD
    61  TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE
   121  WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS
   181  KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS
   241  TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
   301  LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE
   361  ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ
   421  ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 31 nTPM
  • thymus: 21 nTPM
  • adipose tissue: 16 nTPM
  • liver: 14 nTPM
  • skeletal muscle: 12 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • late primary spermatocytes: 83 nCPM
  • early spermatids: 60 nCPM
  • neutrophils: 56 nCPM
  • platelets: 54 nCPM
  • suprabasal keratinocytes: 51 nCPM
  • erythrocyte progenitors: 50 nCPM

Immune cell

  • basophil: 22 nTPM
  • neutrophil: 18 nTPM
  • NK-cell: 14 nTPM
  • MAIT T-cell: 11 nTPM
  • memory CD4 T-cell: 8.1 nTPM
  • naive CD4 T-cell: 8.1 nTPM

Brain region

  • white matter: 19 nTPM
  • medulla oblongata: 17 nTPM
  • basal ganglia: 17 nTPM
  • spinal cord: 17 nTPM
  • midbrain: 16 nTPM
  • cerebellum: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.21
DepMap mean gene effect
-1.8
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDE2 as an antibody target. Whether an autoantibody or antibody against SDE2 could matter depends on whether native SDE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SDE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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