BORCS7
BLOC-1-related complex subunit 7
Also known as: BORC7_HUMAN, C10orf32, FLJ40752
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96B45
- Gene
- BORCS7
- Ensembl
- ENSG00000166275
- Chromosome
- 10
- Canonical length
- 106 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Cytosol
OverviewNCBI Gene
Predicted to be involved in organelle transport along microtubule; regulation of endosome size; and regulation of lysosome size. Predicted to act upstream of or within several processes, including lysosome localization; motor behavior; and response to cycloheximide. Part of BORC complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
106 residues, UniProt reviewed canonical sequence.
>Q96B45|BORCS7
1 MMATGTPESQ ARFGQSVKGL LTEKVTTCGT DVIALTKQVL KGSRSSELLG QAARNMVLQE
61 DAILHSEDSL RKMAIITTHL QYQQEAIQKN VEQSSDLQDQ LNHLLKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BORCS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 63 nTPM
Expression across tissuesHPA
Tissue
- liver: 63 nTPM
- adrenal gland: 55 nTPM
- thyroid gland: 52 nTPM
- parathyroid gland: 50 nTPM
- kidney: 37 nTPM
- basal ganglia: 33 nTPM
Single-cell type
- ependymal cells: 34 nCPM
- oligodendrocytes: 31 nCPM
- other brain neurons: 30 nCPM
- brain inhibitory neurons: 29 nCPM
- brain excitatory neurons: 27 nCPM
- bergmann glia: 27 nCPM
Immune cell
- plasmacytoid DC: 47 nTPM
- intermediate monocyte: 35 nTPM
- non-classical monocyte: 33 nTPM
- basophil: 32 nTPM
- classical monocyte: 30 nTPM
- NK-cell: 28 nTPM
Brain region
- hypothalamus: 20 nTPM
- white matter: 19 nTPM
- spinal cord: 19 nTPM
- choroid plexus: 19 nTPM
- midbrain: 17 nTPM
- medulla oblongata: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
OntologyGO
Biological processes
- axon development
- lysosome localization
- motor behavior
- neuromuscular process
- organelle transport along microtubule
- regulation of endosome size
- regulation of lysosome size
- response to cycloheximide
- vesicle-mediated transport
- walking behavior
Cellular components
Protein domainsUniProt · Pfam · InterPro
- BLOC-1-related complex subunit 7
- BLOC-1-related complex sub-unit 7
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BORCS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BORCS7 as an antibody target. Whether an autoantibody or antibody against BORCS7 could matter depends on whether native BORCS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BORCS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BORCS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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