Bromo adjacent homology (BAH) domain
IPR001025
Definition
The BAH (bromo-adjacent homology) is commonly found in chromatin-associated proteins PMID:23907388. It is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases [interpro:IPR001525], the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation PMID:10100640.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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