DPY30
Protein dpy-30 homolog
Also known as: Cps25, DPY30_HUMAN, HDPY-30, Saf19
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9C005
- Gene
- DPY30
- Ensembl
- ENSG00000162961
- Chromosome
- 2
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q9C005|DPY30
1 MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS LPTRAYLDQT
61 VVPILLQGLA VLAKERPPNP IEFLASYLLK NKAQFEDRNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DPY30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 85 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 85 nTPM
- spinal cord: 82 nTPM
- choroid plexus: 81 nTPM
- hypothalamus: 80 nTPM
- liver: 79 nTPM
- thyroid gland: 76 nTPM
Single-cell type
- esophageal apical cells: 465 nCPM
- fallopian tube ciliated cells: 456 nCPM
- oocytes: 428 nCPM
- epididymal efferent duct ciliated cells: 397 nCPM
- endometrial ciliated cells: 359 nCPM
- respiratory ciliated cells: 322 nCPM
Immune cell
- T-reg: 201 nTPM
- basophil: 178 nTPM
- memory B-cell: 167 nTPM
- eosinophil: 151 nTPM
- naive B-cell: 136 nTPM
- memory CD4 T-cell: 134 nTPM
Brain region
- white matter: 54 nTPM
- medulla oblongata: 47 nTPM
- choroid plexus: 46 nTPM
- hypothalamus: 46 nTPM
- spinal cord: 45 nTPM
- pons: 45 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0.18
- gnomAD missense Z
- 1.47
- DepMap mean gene effect
- -0.39
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Dpy-30 motif
- Sdc1/DPY30
- Dpy-30 motif
- DPY30/SDC1, dimerization/docking domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DPY30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DPY30 as an antibody target. Whether an autoantibody or antibody against DPY30 could matter depends on whether native DPY30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DPY30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DPY30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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