WDR7

Protein identityUniProt · HPA

UniProt accession

Q9Y4E6

Gene

WDR7

Ensembl

ENSG00000091157

Chromosome

18

Canonical length

1490 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1490 residues, UniProt reviewed canonical sequence.

>Q9Y4E6|WDR7
     1  MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV ELQINPRALL
    61  FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR CIEFTKLACT HTGIQFYQFS
   121  VGNQREGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAL
   181  SVTGILKVWI VTSEISDMQD TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV
   241  FDAGDYSLLC SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
   301  GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS GRLNIWNISD
   361  TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
   421  LVCGREDGSI VIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
   481  DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH
   541  SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
   601  ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
   661  SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
   721  QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD DEEEDEEIMR QRREESDPEY
   781  RSSKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
   841  GGHMSLMLPG YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
   901  LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV AAPVVSARSD
   961  ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG LDKFRPPLLE MLARRWQDRC
  1021  LEVREAAQAL LLAELRRIEQ AGRKEAIDAW APYLPQYIDH VISPGVTSEA AQTITTAPDA
  1081  SGPEAKVQEE EHDLVDDDIT TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE
  1141  IEPPKLLTRP RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
  1201  AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD SARSARHALS
  1261  LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA RAKGEILRVI EILIEKMPTD
  1321  VVDLLVEVMD IIMYCLEGSL VKKKGLQECF PAICRFYMVS YYERNHRIAV GARHGSVALY
  1381  DIRTGKCQTI HGHKGPITAV AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ
  1441  LRCIKTYQVP PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.18

gnomAD pLI

1

gnomAD missense Z

2.48

DepMap mean gene effect

-0.77

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• hematopoietic progenitor cell differentiation

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• WD40 repeat
• Quinoprotein alcohol dehydrogenase-like superfamily
• WD40/YVTN repeat-like-containing domain superfamily
• WD40 repeat, conserved site
• WD40-repeat-containing domain superfamily
• WD repeat-containing protein 72-like
• WDR72-like, alpha-solenoid domain
• WD domain, G-beta repeat
• WDR72, alpha-solenoid domain

KeywordsUniProt

• Phosphoprotein
• Repeat
• WD repeat

InteractionsUniProt · HPA

Protein binding partners of WDR7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP6V1B2
• ATP6V1G1