Seroatlas · Human Serome Atlas

WDR45B

WD repeat domain phosphoinositide-interacting protein 3

Also known as: WDR45L, WIPI3, WIPI3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5MNZ6
Gene
WDR45B
Ensembl
ENSG00000141580
Chromosome
17
Canonical length
344 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q5MNZ6|WDR45B
     1  MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML
    61  FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI
   121  KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD
   181  IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ
   241  DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA
   301  FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR45B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 70 nTPM
  • esophagus: 67 nTPM
  • midbrain: 60 nTPM
  • amygdala: 59 nTPM
  • basal ganglia: 57 nTPM
  • ovary: 56 nTPM

Single-cell type

  • late spermatids: 711 nCPM
  • esophageal apical cells: 498 nCPM
  • mast cells: 400 nCPM
  • oocytes: 276 nCPM
  • endometrial glandular cells: 271 nCPM
  • endometrial luminal cells: 232 nCPM

Immune cell

  • basophil: 34 nTPM
  • eosinophil: 34 nTPM
  • intermediate monocyte: 28 nTPM
  • classical monocyte: 28 nTPM
  • non-classical monocyte: 23 nTPM
  • myeloid DC: 22 nTPM

Brain region

  • white matter: 75 nTPM
  • basal ganglia: 68 nTPM
  • thalamus: 68 nTPM
  • spinal cord: 67 nTPM
  • medulla oblongata: 64 nTPM
  • cerebellum: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR45B.

Disease | AllUniProt

Conditions WDR45B is implicated in, by any mechanism.

  • Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures (NEDSBAS) MIM:617977

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 61 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.16
gnomAD missense Z
1.01
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR45B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR45B as an antibody target. Whether an autoantibody or antibody against WDR45B could matter depends on whether native WDR45B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR45B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR45B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR45B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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