Seroatlas · Human Serome Atlas

ID2

DNA-binding protein inhibitor ID-2

Also known as: bHLHb26, GIG8, ID2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02363
Gene
ID2
Ensembl
ENSG00000115738
Chromosome
2
Canonical length
134 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies,Centrosome

OverviewNCBI Gene

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q02363|ID2
     1  MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS
    61  KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF
   121  PSELMSNDSK ALCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ID2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
1,137 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 1,137 nTPM
  • blood vessel: 790 nTPM
  • liver: 539 nTPM
  • bone marrow: 368 nTPM
  • thyroid gland: 209 nTPM
  • ovary: 209 nTPM

Single-cell type

  • cdc: 1,027 nCPM
  • innate lymphoid cells: 878 nCPM
  • endometrial luminal cells: 854 nCPM
  • mast cells: 840 nCPM
  • goblet cells: 804 nCPM
  • syncytiotrophoblasts: 761 nCPM

Immune cell

  • eosinophil: 1,041 nTPM
  • NK-cell: 883 nTPM
  • gdT-cell: 358 nTPM
  • naive CD8 T-cell: 263 nTPM
  • memory CD8 T-cell: 252 nTPM
  • non-classical monocyte: 250 nTPM

Brain region

  • cerebral cortex: 162 nTPM
  • white matter: 115 nTPM
  • thalamus: 107 nTPM
  • hypothalamus: 100 nTPM
  • basal ganglia: 99 nTPM
  • pons: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.67
gnomAD missense Z
0.02
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ID2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ID2 as an antibody target. Whether an autoantibody or antibody against ID2 could matter depends on whether native ID2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ID2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ID2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ID2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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