Seroatlas · Human Serome Atlas

KLF5

Krueppel-like factor 5

Also known as: BTEB2, CKLF, IKLF, KLF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13887
Gene
KLF5
Ensembl
ENSG00000102554
Chromosome
13
Canonical length
457 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q13887|KLF5
     1  MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA
    61  QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV
   121  DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP
   181  APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP
   241  SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF
   301  PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN
   361  RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL
   421  TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
227 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 227 nTPM
  • skin: 222 nTPM
  • colon: 151 nTPM
  • small intestine: 138 nTPM
  • rectum: 137 nTPM
  • duodenum: 123 nTPM

Single-cell type

  • ocular epithelial cells: 1,698 nCPM
  • esophageal apical cells: 1,306 nCPM
  • endometrial glandular cells: 1,230 nCPM
  • epididymal basal cells: 1,194 nCPM
  • suprabasal keratinocytes: 1,077 nCPM
  • urothelial cells: 1,022 nCPM

Immune cell

  • basophil: 24 nTPM
  • eosinophil: 1.1 nTPM
  • neutrophil: 0.5 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM

Brain region

  • basal ganglia: 18 nTPM
  • amygdala: 8.3 nTPM
  • hypothalamus: 8.3 nTPM
  • midbrain: 6.7 nTPM
  • choroid plexus: 5.3 nTPM
  • cerebral cortex: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLF5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Dilated cardiomyopathy 1FF

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.82
gnomAD missense Z
1.58
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF5 as an antibody target. Whether an autoantibody or antibody against KLF5 could matter depends on whether native KLF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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