Seroatlas · Human Serome Atlas

FHIP1A

FHF complex subunit HOOK-interacting protein 1A

Also known as: FAM160A1, FHI1A_HUMAN, FHIP-L, FLJ43373

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05DH4
Gene: FHIP1A
Ensembl: ENSG00000164142
Chromosome: 4
Canonical length: 1040 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in protein localization to perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1040 residues, UniProt reviewed canonical sequence.

>Q05DH4|FHIP1A
     1  MMSSVSTESK LQQAVSLQGV DPETCMIVFK NHWAQVVKIL EKHDPLKNTQ AKYGSIPPDE
    61  ASAVQNYVEH MLFLLIEEQA KDAAMGPILE FVVSENIMEK LFLWSLRREF TDETKIEQLK
   121  MYEMLVTQSH QPLLHHKPIL KPLMMLLSSC SGTTTPTVEE KLVVLLNQLC SILAKDPSIL
   181  ELFFHTSEDQ GAANFLIFSL LIPFIHREGS VGQQARDALL FIMSLSAENT MVAHHIVENT
   241  YFCPVLATGL SGLYSSLPTK LEEKGEEWHC LLKDDWLLLP SLVQFMNSLE FCNAVIQVAH
   301  PLIRNQLVNY IYNGFLVPVL APALHKVTVE EVMTTTAYLD LFLRSISEPA LLEIFLRFIL
   361  LHQHENVHIL DTLTSRINTP FRLCVVSLAL FRTLIGLHCE DVMLQLVLRY LIPCNHMMLS
   421  QRWAVKERDC YSVSAAKLLA LTPVCCSSGI TLTLGNQERD YILWSKCMHD TSGPVERPFP
   481  EAFSESACIV EYGKALDISY LQYLWEAHTN ILRCMRDCRV WSALYDGDSP DPEMFLQSLT
   541  EEGSVSSACP VFGLPQQLPR KTGPQLAPRK DKSQTELEWD DSYDTGISSG ADVGSPGPYD
   601  DLEVSGPPAP IDPPKHIQEM KKNALLLFKG SYIEESDFQD DVMVYRLCAE KDSEDMKDSQ
   661  EEAARPPAEA QAEVQSVPIN NGPLLSTQPE TDSEEEWNRD NSDPFHSEPK EPKQEREPEA
   721  APESNSELAS PAPEAEHSSN LTAAHPESEE LIAQYDQIIK ELDSGAEGLM EQNYPTPDPL
   781  LLTKEEEGKE ESKGEKEKEG KKELEDEEDD FDSFIAEMPA VETVPSPFVG RDEAAFASRH
   841  PVRTQSTPFT GPFISVVLSK LENMLENSLH VNLLLIGIIT QLASYPQPLL RSFLLNTNMV
   901  FQPSVRSLYQ VLASVKNKIE QFASVERDFP GLLIQAQQYL LFRVDMSDMT PAALTKDPIQ
   961  EASRTGSGKN LLDGPPRVLQ PFLTHRTKVA EAPPNLPLPV RNPMLAAALF PEFLKELAAL
  1021  AQEHSILCYK ILGDFEDSCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FHIP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
tongue: 15 nTPM
skin: 13 nTPM
pancreas: 9.6 nTPM
parathyroid gland: 7.8 nTPM
esophagus: 7.6 nTPM

Single-cell type

salivary basal cells: 1,231 nCPM
endometrial glandular cells: 1,217 nCPM
myonuclei: 1,072 nCPM
endometrial luminal cells: 1000 nCPM
choroid plexus epithelial cells: 989 nCPM
urothelial cells: 933 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
basophil: 0.1 nTPM
myeloid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 69 nTPM
cerebellum: 29 nTPM
cerebral cortex: 4 nTPM
hippocampal formation: 3.3 nTPM
amygdala: 3 nTPM
basal ganglia: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FHIP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AKTIP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FHIP1A as an antibody target. Whether an autoantibody or antibody against FHIP1A could matter depends on whether native FHIP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FHIP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FHIP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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