Seroatlas · Human Serome Atlas

AKAP3

A-kinase anchor protein 3

Also known as: AKAP110, AKAP3_HUMAN, CT82, FSP95, SOB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75969
Gene: AKAP3
Ensembl: ENSG00000111254
Chromosome: 12
Canonical length: 853 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol,Principal piece

OverviewNCBI Gene

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

853 residues, UniProt reviewed canonical sequence.

>O75969|AKAP3
     1  MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE KSTAEFQDVR
    61  FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE MTHKEIPCQG PRAQLGNGSS
   121  VDEVSFYANR LTNLVIAMAR KEINEKIDGS ENKCVYQSLY MGNEPTPTKS LSKIASELVN
   181  ETVSACSRNA APDKAPGSGD RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF
   241  FYKEVFESRN GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI
   301  MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT DTQFVSAVKR
   361  TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK AESYSLISMK GMGDPKNRNV
   421  NFAMKSETKL REKMYSEPKS EEETCAKTLG EHIIKEGLTL WHKTQQKECK SLGFQHAAFE
   481  APNTQRKPAS DISFEYPEDI GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA
   541  QGGRRDARSF VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN
   601  LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL SGLTKMAVSQ
   661  IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS GDASRLTSAF PDSLYECLPA
   721  KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV
   781  AASELNVPIL YFAGDDEGIQ EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV
   841  TPLQLLDWLM VNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

testis: 94 nTPM
heart muscle: 4 nTPM
epididymis: 2.6 nTPM
fallopian tube: 2.2 nTPM
kidney: 2.1 nTPM
spinal cord: 2.1 nTPM

Single-cell type

early spermatids: 983 nCPM
late spermatids: 479 nCPM
late primary spermatocytes: 272 nCPM
early primary spermatocytes: 13 nCPM
epididymal principal cells: 12 nCPM
respiratory ionocytes: 7.6 nCPM

Immune cell

naive CD8 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.5 nTPM
NK-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

white matter: 5.3 nTPM
basal ganglia: 4.7 nTPM
cerebellum: 4.4 nTPM
medulla oblongata: 4.3 nTPM
spinal cord: 3.8 nTPM
midbrain: 3.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AKAP3.

Disease | AllUniProt

Conditions AKAP3 is implicated in, by any mechanism.

Spermatogenic failure 82 (SPGF82) MIM:620353

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 141 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 82

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.06
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase A binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAP3 as an antibody target. Whether an autoantibody or antibody against AKAP3 could matter depends on whether native AKAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...