Seroatlas · Human Serome Atlas

ROPN1B

Ropporin-1B

Also known as: ROP1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZX4
Gene: ROPN1B
Ensembl: ENSG00000114547
Chromosome: 3
Canonical length: 212 aa
Protein class: Predicted intracellular proteins
Subcellular location: Principal piece
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>Q9BZX4|ROPN1B
     1  MAQTDKPTCI PPELPKMLKE FAKAAIRAQP QDLIQWGADY FEALSRGETP PVRERSERVA
    61  LCNWAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP TDLFNSVMNV GRFTEEIEWL
   121  KFLALACSAL GVTITKTLKI VCEVLSCDHN GGLPRIPFST FQFLYTYIAE VDGEICASHV
   181  SRMLNYIEQE VIGPDGLITV NDFTQNPRVW LE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ROPN1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 205 nTPM

Expression across tissuesHPA

Tissue

testis: 205 nTPM
breast: 36 nTPM
epididymis: 21 nTPM
salivary gland: 14 nTPM
skin: 6.8 nTPM
basal ganglia: 3 nTPM

Single-cell type

late spermatids: 2,378 nCPM
early spermatids: 2,019 nCPM
late primary spermatocytes: 1,857 nCPM
melanocytes: 154 nCPM
breast secretory cells: 95 nCPM
lacrimal acinar cells: 73 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 6.4 nTPM
white matter: 6.4 nTPM
cerebral cortex: 6 nTPM
amygdala: 4.9 nTPM
basal ganglia: 4.8 nTPM
midbrain: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ropporin, dimerization/docking domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ROPN1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ROPN1B as an antibody target. Whether an autoantibody or antibody against ROPN1B could matter depends on whether native ROPN1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ROPN1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ROPN1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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