Seroatlas · Human Serome Atlas

ROPN1L

Ropporin-1-like protein

Also known as: ASP, FLJ25776, ROP1L_HUMAN, RSPH11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C74
Gene: ROPN1L
Ensembl: ENSG00000145491
Chromosome: 5
Canonical length: 230 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Primary cilium transition zone,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q96C74|ROPN1L
     1  MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLR WSAGYFSALS RGDPLPVKDR
    61  MEMPTATQKT DTGLTQGLLK VLHKQCHHKR YVELTDLEQK WKNLCLPKEK FKALLQLDPC
   121  ENKIKWINFL ALGCSMLGGS LNTALKHLCE ILTDDPEGGP ARIPFKTFSY VYRYLARLDS
   181  DVSPLETESY LASLKENIDA RKNGMIGLSD FFFPKRKLLE SIENSEDVGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ROPN1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 304 nTPM

Expression across tissuesHPA

Tissue

testis: 304 nTPM
fallopian tube: 26 nTPM
choroid plexus: 11 nTPM
hippocampal formation: 5.7 nTPM
lung: 5.3 nTPM
hypothalamus: 4.5 nTPM

Single-cell type

late spermatids: 4,288 nCPM
late primary spermatocytes: 3,415 nCPM
early spermatids: 2,979 nCPM
respiratory ciliated cells: 651 nCPM
fallopian tube ciliated cells: 558 nCPM
epididymal efferent duct ciliated cells: 434 nCPM

Immune cell

neutrophil: 106 nTPM
eosinophil: 55 nTPM
basophil: 45 nTPM
T-reg: 5.8 nTPM
memory CD8 T-cell: 4.7 nTPM
gdT-cell: 4.1 nTPM

Brain region

midbrain: 20 nTPM
choroid plexus: 15 nTPM
medulla oblongata: 12 nTPM
spinal cord: 9.9 nTPM
pons: 5.6 nTPM
white matter: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ropporin, dimerization/docking domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ROPN1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ROPN1L as an antibody target. Whether an autoantibody or antibody against ROPN1L could matter depends on whether native ROPN1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ROPN1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ROPN1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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